Details:

Alternative Title:
Prev Chronic Dis
Personal Author:
Patel, Alpa V. ; Hodge, James M. ; Rees-Punia, Erika ; Teras, Lauren R. ; Campbell, Peter T. ; ... More +
Patel, Alpa V. ; Hodge, James M. ; Rees-Punia, Erika ; Teras, Lauren R. ; Campbell, Peter T. ; Gapstur, Susan M. Less -
Description:
Introduction

Muscle-strengthening activity (MSA) has beneficial effects on hypertension, glucose homeostasis, and other health conditions; however, its association with mortality is not as well understood.

Methods

We analyzed data from the Cancer Prevention Study-II Nutrition Cohort (data collection 1982–2014), a prospective US cohort that consisted of 72,462 men and women who were free of major chronic diseases; 18,034 of the cohort died during 13 years of follow-up (2001–2014). We used Cox proportional hazards modeling, controlling for various potential confounding factors, to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for MSA (none, >0 to <1 h/wk, 1 to <2 h/wk, and ≥2 h/wk) in relation to mortality risk, independent of and in combination with aerobic physical activity.

Results

The association between MSA and mortality appeared to be nonlinear (quadratic trend P value, <.001). After multivariable adjustment and comparison with no MSA, engaging in less than 2 hours per week of MSA was associated with lowered all-cause mortality (>0 to <1 h/wk: HR = 0.88, 95% CI, 0.82–0.94; 1 to <2 h/wk: HR = 0.90, 95% CI, 0.84–0.97), but engaging in 2 or more hours per week was not associated with reduced risk (HR = 1.01; 95% CI, 0.92–1.09). Associations were similar but not significant for cancer mortality. Engaging in >0 to <1 hr/wk of MSA was associated with a 19% lower risk (HR = 0.81; 95% CI, 0.71–0.92) of cardiovascular disease mortality, but more time spent in MSA was not associated with reduced risk (quadratic trend P value =.005). Associations did not vary by amount of moderate-to-vigorous aerobic physical activity.

Conclusion

Engaging in ≥2 hours per week of MSA was associated with lower all-cause mortality, independent of aerobic activity. Reasons for the lack of association with higher amounts of MSA are unclear. Our findings support recommending muscle-strengthening activities for overall health.


Subjects:
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Original Research
Source:
Prev Chronic Dis. 2020; 17
Pubmed ID:
32762807
Pubmed Central ID:
PMC7417019
Document Type:
Journal Article
Collection(s):
Preventing Chronic Disease
Main Document Checksum:
[+]
urn:sha256:92d5411ca565a0a12689bb1ac3a03785ba52316e9e1974cfcf8b50842618da83
Download URL:
https://stacks.cdc.gov/view/cdc/92135/cdc_92135_DS1.pdf
File Type:

Supporting Files

• PCD-17-E78.nxml

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