Relationship Between Muscle-Strengthening Activity and Cause-Specific Mortality in a Large US Cohort

Details

• Journal Article:
  Preventing Chronic Disease (PCD)
• Personal Author:
  Patel, Alpa V. ; Hodge, James M. ; Rees-Punia, Erika ; Teras, Lauren R. ; Campbell, Peter T. ; Gapstur, Susan M.
• Description:
  Introduction
  
  Muscle-strengthening activity (MSA) has beneficial effects on hypertension, glucose homeostasis, and other health conditions; however, its association with mortality is not as well understood.
  
  Methods
  
  We analyzed data from the Cancer Prevention Study-II Nutrition Cohort (data collection 1982–2014), a prospective US cohort that consisted of 72,462 men and women who were free of major chronic diseases; 18,034 of the cohort died during 13 years of follow-up (2001–2014). We used Cox proportional hazards modeling, controlling for various potential confounding factors, to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for MSA (none, >0 to <1 h/wk, 1 to <2 h/wk, and ≥2 h/wk) in relation to mortality risk, independent of and in combination with aerobic physical activity.
  
  Results
  
  The association between MSA and mortality appeared to be nonlinear (quadratic trend P value, <.001). After multivariable adjustment and comparison with no MSA, engaging in less than 2 hours per week of MSA was associated with lowered all-cause mortality (>0 to <1 h/wk: HR = 0.88, 95% CI, 0.82–0.94; 1 to <2 h/wk: HR = 0.90, 95% CI, 0.84–0.97), but engaging in 2 or more hours per week was not associated with reduced risk (HR = 1.01; 95% CI, 0.92–1.09). Associations were similar but not significant for cancer mortality. Engaging in >0 to <1 hr/wk of MSA was associated with a 19% lower risk (HR = 0.81; 95% CI, 0.71–0.92) of cardiovascular disease mortality, but more time spent in MSA was not associated with reduced risk (quadratic trend P value =.005). Associations did not vary by amount of moderate-to-vigorous aerobic physical activity.
  
  Conclusion
  
  Engaging in ≥2 hours per week of MSA was associated with lower all-cause mortality, independent of aerobic activity. Reasons for the lack of association with higher amounts of MSA are unclear. Our findings support recommending muscle-strengthening activities for overall health.
  
  
• Subjects:
  Original Research
• Source:
  Prev Chronic Dis. 2020; 17
• ISSN:
  1545-1151
• Pubmed ID:
  32762807
• Pubmed Central ID:
  PMC7417019
• Document Type:
  Journal Article
• Volume:
  17
• Collection(s):
  Preventing Chronic Disease
• Main Document Checksum:
  urn:sha-512:f834a3398b263e42af860ae3094c715a03ecd68a751aa40a3ea4f254ee1cb8c51132bb5ab838eb99921f552cbc0e149705bc362616e8500a949457385de20e6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/92135/cdc_92135_DS1.pdf
• File Type:
  [PDF - 412.10 KB ]