Update on Extensively Drug-Resistant Salmonella Serotype Typhi Infections Among Travelers to or from Pakistan and Report of Ceftriaxone-Resistant Salmonella Serotype Typhi Infections Among Travelers to Iraq — United States, 2018–2019

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  François Watkins, Louise K. ; Winstead, Alison ; Appiah, Grace D. ; Friedman, Cindy R. ; Medalla, Felicita ; Hughes, Michael J. ; Birhane, Meseret G. ; Schneider, Zachary D. ; Marcenac, Perrine ; Hanna, Samir S. ; Godbole, Gauri ; Walblay, Kelly A . ; Wiggington, Ashley E. ; Leeper, Molly ; Meservey, Elizabeth H. ; Tagg, Kaitlin A. ; Chen, Jessica C. ; Abubakar, Abdinasir ; Lami, Faris ; Asaad, Asaad M. ; Sabaratnam, Vickneswaran ; Ikram, Aamer ; Angelo, Kristina M. ; Walker, Allison ; Mintz, Eric
• Description:
  Ceftriaxone-resistant Salmonella enterica serotype Typhi (Typhi), the bacterium that causes typhoid fever, is a growing public health threat. Extensively drug-resistant (XDR) Typhi is resistant to ceftriaxone and other antibiotics used for treatment, including ampicillin, chloramphenicol, ciprofloxacin, and trimethoprim-sulfamethoxazole (1). In March 2018, CDC began enhanced Surveillance for ceftriaxone-resistant Typhi in response to an ongoing outbreak of XDR typhoid fever in Pakistan. CDC had previously reported the first five cases of XDR Typhi in the United States among patients who had spent time in Pakistan (2). These illnesses represented the first cases of ceftriaxone-resistant Typhi documented in the United States (3). This report provides an update on U.S. cases of XDR typhoid fever linked to Pakistan and describes a new, unrelated cluster of ceftriaxone-resistant Typhi infections linked to Iraq. Travelers to areas with endemic Typhi should receive typhoid vaccination before traveling and adhere to safe food and water precautions (4). Treatment of patients with typhoid fever should be guided by antimicrobial susceptibility tTesting whenever possible (5), and clinicians should consider travel History when selecting empiric therapy.
• Subjects:
  Adolescent Adult Aged Ceftriaxone Child Child, Preschool Disease Outbreaks Drug Resistance, Microbial Female Full Report Humans Infant Male Middle Aged Salmonella Typhi Travel-Related Illness Typhoid Fever Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 69(20):618-622
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  32437343
• Pubmed Central ID:
  PMC7357342
• Document Type:
  Journal Article
• Place as Subject:
  Iraq ; Pakistan ; United States
• Pages in Document:
  5 pdf pages
• Volume:
  69
• Issue:
  20
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:3efdc8556084c71ad3721a237df3540c119f6a86f1d8313c25496d6c06d9609db5ac92c5799fd2182511b23f75aa6354cc7c4b7b8d4262b3f5b6842c757371eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/91079/cdc_91079_DS1.pdf
• File Type:
  [PDF - 160.83 KB ]