Details:

Alternative Title:
Epilepsia
Personal Author:
Sajatovic, Martha ; Johnson, Erica K. ; Fraser, Robert T. ; Cassidy, Kristin A. ; Liu, Hongyan ; ... More +
Sajatovic, Martha ; Johnson, Erica K. ; Fraser, Robert T. ; Cassidy, Kristin A. ; Liu, Hongyan ; Pandey, Dilip K. ; Quarells, Rakale C. ; Scal, Peter ; Schmidt, Samantha ; Shegog, Ross ; Spruill, Tanya M. ; Janevic, Mary R. ; Tatsuoka, Curtis ; Jobst, Barbara C. Less -
Description:
Summary

Objective:

To assess depressive symptom outcomes in a pooled sample of epilepsy self-management randomized controlled trials (RCTs) from the Managing Epilepsy Well (MEW) Network integrated research database (MEW DB).

Study Design and Setting (Methods):

Five prospective RCTs involving 453 adults with epilepsy compared self-management intervention (n=232) vs. treatment as usual or wait-list control outcomes (n=221). Depression was assessed with the 9-item Patient Health Questionnaire (PHQ-9). Other variables included age, gender, race, ethnicity, education, income, marital status, seizure frequency and quality of life. Follow-up assessments were collapsed into a visit 2 and a visit 3; these were conducted post-baseline.

Results:

Mean age was 43.5 (SD 12.6), nearly 2/3 women and nearly 1/3 African-American. Baseline sample characteristics were mostly similar in the self-management intervention group vs. controls. At follow-up the self-management group had a significantly greater reduction in depression compared to controls at visit 2 (P <.0001) and visit 3 (P=.0002). Quality of life also significantly improved in self-management group at visit 2 (P=.001) and 3 (P=.005).

Conclusions:

Aggregate MEW DB analysis of five RCTs found depressive symptom severity and quality of life significantly improved in individuals randomized to self-management intervention vs. controls. Evidence-based epilepsy self-management programs should be made more broadly available in neurology practices.


Subject:
[+]
Adaptation, Psychological
Adult
Article
Databases, Factual
Depression
Epilepsy
Female
Humans
Male
Middle Aged
Prospective Studies
Quality Of Life
Seizures
Self-management
Depression
Epilepsy
Quality Of Life
Self-Management

Source:
Epilepsia. 60(9):1921-1931
Pubmed ID:
31486072
Pubmed Central ID:
PMC7370538
Document Type:
Journal Article
Funding:
U48 DP005030/DP/NCCDPHP CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c89a574bf2b2d12bfbb97c1c914af4136e28070ef0cb234febd055a8a25c44d2
File Type:

Supporting Files

• 	nihms-1592221-f0001.gif	gif
  	nihms-1592221-f0001.jpg	jpeg
  	nihms-1592221.nxml	xml

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