Maintenance of bone mass despite estrogen depletion in female common marmoset monkeys (Callithrix jacchus)

Details

• Alternative Title:
  Am J Primatol
• Personal Author:
  Saltzman, Wendy ; Abbott, David H. ; Binkley, Neil ; Colman, Ricki J.
• Description:
  Estrogen depletion leads to bone loss in almost all mammals with frequent regular ovarian cycles. However, subordinate adult female common marmosets (Callithrix jacchus) undergo socially induced anovulation and hypoestrogenism without clinically apparent adverse skeletal consequences. Thus, we speculated that this non human primate might have evolved a mechanism to avoid estrogen-depletion bone loss. To test this possibility, we performed three experiments in which lumbar-spine (L5-L6) bone mineral content (BMC) and density (BMD) were assessed using dual-energy X-ray absorptiometry: (i) cross-sectionally in 13 long-term ovariectomized animals and 12 age- and weight-matched controls undergoing ovulatory cycles; (ii) longitudinally in 12 animals prior to, 3-4 and 6-7 months following ovariectomy (ovx), and six controls; and (iii) cross-sectionally in nine anovulatory subordinate and nine dominant females. In Experiments 1 and 3, plasma estradiol and estrone concentrations were measured and uterine dimensions were obtained by ultrasound in a subset of animals as a marker of functional estrogen depletion. Estrogen levels, uterine trans-fundus width, and uterine dorso-ventral diameter were lower in ovariectomized and subordinate females than in those undergoing ovulatory cycles. However, no differences were found in L5-L6 BMC or BMD. These results indicate that estrogen depletion, whether surgically or socially induced, is not associated with lower bone mass in female common marmosets. Thus, this species may possess unique adaptations to avoid bone loss associated with estrogen depletion.
• Subjects:
  Animals Anovulation Article Bone Bone Density Callithrix Estradiol Estrogen Estrogens Estrone Female Lumbar Vertebrae Marmoset Menstrual Cycle Osteoporosis Ovariectomy Reproductive Suppression Social Dominance Uterus

  More +
• Source:
  Am J Primatol. 81(2):e22905
• Pubmed ID:
  30106167
• Pubmed Central ID:
  PMC7336524
• Document Type:
  Journal Article
• Funding:
  R03 MH60728/MH/NIMH NIH HHS/United States ; P01 AG11915/AG/NIA NIH HHS/United States ; P01 AG011915/AG/NIA NIH HHS/United States ; R03 AG15621/AG/NIA NIH HHS/United States ; P51 OD011106/OD/NIH HHS/United States ; IBN-9604321/National Science Foundation/International ; P51 OD011106/CD/ODCDC CDC HHS/United States ; R01 MH060728/MH/NIMH NIH HHS/United States
• Volume:
  81
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:092bc516fca8c1584d8eaaec05a7aea8f787223265de7617667ffb7693d0b7fb
• Download URL:
  https://stacks.cdc.gov/view/cdc/90280/cdc_90280_DS1.pdf
• File Type:
  [PDF - 657.69 KB ]