Atypical Manifestations of Cat-Scratch Disease, United States, 2005–2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nawrocki, Courtney C. ; Max, Ryan J. ; Marzec, Natalie S. ; Nelson, Christina A.
• Description:
  Atypical manifestations that can be severe and difficult to diagnosis develop in 5%-20% of patients with cat-scratch disease. To clarify the epidemiology of atypical cat-scratch disease in the United States, we analyzed data from the 2005-2014 MarketScan national health insurance claims databases by using the International Classification of Diseases, 9th Revision, Clinical Modification, codes for cat-scratch disease and selected atypical manifestations: retinitis/neuroretinitis, conjunctivitis, neuritis, encephalitis, hepatosplenic disease, osteomyelitis, erythema nodosum, and endocarditis. Atypical cat-scratch disease accounted for 1.5% of all cases, resulting in an average annual incidence of 0.7 cases/100,000 population. Atypical cat-scratch disease was associated with increased risk for hospitalization (risk ratios 8.77, 95% CI 6.56-11.72) and occurred most often in female patients 10-14 years of age. Ocular (48.7%), hepatosplenic (24.6%), and neurologic (13.8%) manifestations were most common among patients. A more comprehensive understanding of atypical cat-scratch disease can improve patient diagnosis and potentially elucidate pathophysiology of the disease.
• Subjects:
  Bartonella Henselae Cat-Scratch Disease Chorioretinitis Female Humans Incidence Retinitis
• Source:
  Emerg Infect Dis. 26(7):1438-1446
• Pubmed ID:
  32568056
• Pubmed Central ID:
  PMC7323523
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  26
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4d850f1ad3f343b50b2b7a02ba56ab0db53ce18ee55268037f0e187688155805
• Download URL:
  https://stacks.cdc.gov/view/cdc/90181/cdc_90181_DS1.pdf
• File Type:
  [PDF - 1.37 MB ]