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Case Manifestations and Public Health Response for Outbreak of Meningococcal W Disease, Central Australia, 2017
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Jul 2020
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Source: Emerg Infect Dis. 26(7):1355-1363
[PDF-1.12 MB]
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Alternative Title:Emerg Infect Dis
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Description:Neisseria meningitidis serogroup W has emerged as an increasingly common cause of invasive meningococcal disease worldwide; the average case-fatality rate is 10%. In 2017, an unprecedented outbreak of serogroup W infection occurred among the Indigenous pediatric population of Central Australia; there were 24 cases over a 5-month period. Among these cases were atypical manifestations, including meningococcal pneumonia, septic arthritis, and conjunctivitis. The outbreak juxtaposed a well-resourced healthcare system against unique challenges related to covering vast distances, a socially disadvantaged population, and a disease process that was rapid and unpredictable. A coordinated clinical and public health response included investigation of and empiric treatment for 649 febrile children, provision of prophylactic antimicrobial drugs for 465 close contacts, and implementation of a quadrivalent meningococcal ACWY conjugate vaccine immunization program. The response contained the outbreak within 6 months; no deaths and only 1 case of major illness were recorded.
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Pubmed ID:32568047
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Pubmed Central ID:PMC7323526
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Document Type:
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Volume:26
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Issue:7
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