Details:

Alternative Title:
PLoS Negl Trop Dis
Personal Author:
Amman, Brian R. ; Schuh, Amy J. ; Sealy, Tara K. ; Spengler, Jessica R. ; Welch, Stephen R. ; ... More +
Amman, Brian R. ; Schuh, Amy J. ; Sealy, Tara K. ; Spengler, Jessica R. ; Welch, Stephen R. ; Kirejczyk, Shannon G. M. ; Albariño, César G. ; Nichol, Stuart T. ; Towner, Jonathan S. Less -
Description:
In August 2012, a wildlife biologist became severely ill after becoming infected with a novel paramyxovirus, termed Sosuga virus. In the weeks prior to illness, the patient worked with multiple species of bats in South Sudan and Uganda, including Egyptian rousette bats (ERBs: Rousettus aegyptiacus). A follow-up study of Ugandan bats found multiple wild-caught ERBs to test positive for SOSV in liver and spleen. To determine the competency of these bats to act as a natural reservoir host for SOSV capable of infecting humans, captive-bred ERBs were inoculated with a recombinant SOSV, representative of the patient's virus sequence. The bats were inoculated subcutaneously, sampled daily (blood, urine, fecal, oral and rectal swabs) and serially euthanized at predetermined time points. All inoculated bats became infected with SOSV in multiple tissues and blood, urine, oral, rectal and fecal swabs tested positive for SOSV RNA. No evidence of overt morbidity or mortality were observed in infected ERBs, although histopathological examination showed subclinical disease in a subset of tissues. Importantly, SOSV was isolated from oral/rectal swabs, urine and feces, demonstrating shedding of infectious virus concomitant with systemic infection. All bats euthanized at 21 days post-inoculation (DPI) seroconverted to SOSV between 16 and 21 DPI. These results are consistent with ERBs being competent reservoir hosts for SOSV with spillover potential to humans.
Subject:
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Animals
Chiroptera
Disease Reservoirs
Disease Transmission, Infectious
Humans
Male
Paramyxoviridae
Paramyxoviridae Infections
Viral Tropism

Source:
PLoS Negl Trop Dis. 14(3)
Pubmed ID:
32119657
Pubmed Central ID:
PMC7067492
Document Type:
Journal Article
Place as Subject:
Uganda
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8b93e845ef1f7b897072cae00e9a4f4dfb7bcef51158b64d5dc352bd63460c20
File Type:

Supporting Files

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