Estimated Burden of Community-Onset Respiratory Syncytial Virus–Associated Hospitalizations Among Children Aged <2 Years in the United States, 2014–15

Details

• Alternative Title:
  J Pediatric Infect Dis Soc
• Personal Author:
  Arriola, Carmen S ; Kim, Lindsay ; Langley, Gayle ; Anderson, Evan J ; Openo, Kyle ; Martin, Andrew M ; Lynfield, Ruth ; Bye, Erica ; Como-Sabetti, Kathy ; Reingold, Arthur ; Chai, Shua ; Daily, Pam ; Thomas, Ann ; Crawford, Courtney ; Reed, C ; Garg, S ; Chaves, Sandra S
• Description:
  Background
  
  Respiratory syncytial virus (RSV) is a major cause of hospitalizations in young children. We estimated the burden of community-onset RSV-associated hospitalizations among US children aged <2 years by extrapolating rates of RSV-confirmed hospitalizations in 4 surveillance states and using probabilistic multipliers to adjust for ascertainment biases.
  
  Methods
  
  From October 2014 through April 2015, clinician-ordered RSV tests identified laboratory-confirmed RSV hospitalizations among children aged <2 years at 4 influenza hospitalization surveillance network sites. Surveillance populations were used to estimate age-specific rates of RSV-associated hospitalization, after adjusting for detection probabilities. We extrapolated these rates using US census data.
  
  Results
  
  We identified 1554 RSV-associated hospitalizations in children aged <2 years. Of these, 27% were admitted to an intensive care unit, 6% needed mechanical ventilation, and 5 died. Most cases (1047/1554; 67%) had no underlying condition. Adjusted age-specific RSV hospitalization rates per 100 000 population were 1970 (95% confidence interval [CI],1787 to 2177), 897 (95% CI, 761 to 1073), 531 (95% CI, 459 to 624), and 358 (95% CI, 317 to 405) for ages 0–2, 3–5, 6–11, and 12–23 months, respectively. Extrapolating to the US population, an estimated 49 509–59 867 community-onset RSV-associated hospitalizations among children aged <2 years occurred during the 2014–2015 season.
  
  Conclusions
  
  Our findings highlight the importance of RSV as a cause of hospitalization, especially among children aged <2 months. Our approach to estimating RSV-related hospitalizations could be used to provide a US baseline for assessing the impact of future interventions.
  
  
• Subjects:
  Children Disease Burden Original Article RSV
• Source:
  J Pediatric Infect Dis Soc. 2019;
• Pubmed ID:
  31868913
• Pubmed Central ID:
  PMC7107566
• Document Type:
  Journal Article
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cb8f77545666c32bc29e7066d16210cdf6b25d2c53864ffb0e84a44aff810318
• Download URL:
  https://stacks.cdc.gov/view/cdc/89378/cdc_89378_DS1.pdf
• File Type:
  [PDF - 415.63 KB ]