Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

Kaul, Drishti; Rathnasinghe, Raveen; Ferres, Marcela; Tan, Gene S.; Barrera, Aldo; Pickett, Brett E.; Methe, Barbara A.; Das, Suman; Budnik, Isolda; Halpin, Rebecca A.; Wentworth, David; Schmolke, Mirco; Mena, Ignacio; Albrecht, Randy A.; Singh, Indresh; Nelson, Karen E.; García-Sastre, Adolfo; Dupont, Chris L.; Medina, Rafael A.

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Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

Published Date:

May 21 2020

Source:

Nat Commun. 11

Language:

English

[PDF-1.03 MB]

Details:

Alternative Title:

Nat Commun

Personal Author:

Kaul, Drishti ; Rathnasinghe, Raveen ; Ferres, Marcela ; Tan, Gene S. ; Barrera, Aldo ; ... More ▼

Description:

Infection with influenza can be aggravated by bacterial co-infections, which often results in disease exacerbation. The effects of influenza infection on the upper respiratory tract (URT) microbiome are largely unknown. Here, we report a longitudinal study to assess the temporal dynamics of the URT microbiomes of uninfected and influenza virus-infected humans and ferrets. Uninfected human patients and ferret URT microbiomes have stable healthy ecostate communities both within and between individuals. In contrast, infected patients and ferrets exhibit large changes in bacterial community composition over time and between individuals. The unhealthy ecostates of infected individuals progress towards the healthy ecostate, coinciding with viral clearance and recovery. Pseudomonadales associate statistically with the disturbed microbiomes of infected individuals. The dynamic and resilient microbiome during influenza virus infection in multiple hosts provides a compelling rationale for the maintenance of the microbiome homeostasis as a potential therapeutic target to prevent IAV associated bacterial co-infections.

Subject:

[+]

Pubmed ID:

32439901

Pubmed Central ID:

PMC7242466

Document Type:

Journal Article

Funding:

PIA ACT 1408/Ministry of Education, Government of Chile ; Comisión Nacional de Investigación Científica y Tecnológica (National Commission for Scientific and Technological Research)/ ; HHSN272201400008C/AI/NIAID NIH HHS/United States ; P09/016-F/Ministerio de Economía, Fomento y Turismo (Ministry of Economy, Development and Tourism)/ ; FONDECYT 1161791/Ministry of Education, Government of Chile ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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