Biosafety risk assessment for production of candidate vaccine viruses to protect humans from zoonotic highly pathogenic avian influenza viruses

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  Chen, Li‐Mei ; Donis, Ruben O. ; Suarez, David L. ; Wentworth, David E. ; Webby, Richard ; Engelhardt, Othmar G. ; Swayne, David E.
• Description:
  A major lesson learned from the public health response to the 2009 H1N1 pandemic was the need to shorten the vaccine delivery timeline to achieve the best pandemic mitigation results. A gap analysis of previous pre-pandemic vaccine development activities identified possible changes in the Select Agent exclusion process that would maintain safety and shorten the timeline to develop candidate vaccine viruses (CVVs) for use in pandemic vaccine manufacture. Here, we review the biosafety characteristics of CVVs developed in the past 15 years to support a shortened preparedness timeline for A(H5) and A(H7) subtype highly pathogenic avian influenza (HPAI) CVVs. Extensive biosafety experimental evidence supported recent changes in the implementation of Select Agent regulations that eliminated the mandatory chicken pathotype testing requirements and expedited distribution of CVVs to shorten pre-pandemic and pandemic vaccine manufacturing by up to 3 weeks.
• Subjects:
  Animals Birds Containment Of Biohazards Humans Influenza, Human Influenza A Virus, H5N1 Subtype Influenza A Virus, H7N9 Subtype Influenza In Birds Pandemics Poultry Risk Assessment Viral Vaccines Virus Cultivation Zoonoses

  More +
• Source:
  Influenza Other Respir Viruses. 14(2):215-225
• Pubmed ID:
  31659871
• Pubmed Central ID:
  PMC7040978
• Document Type:
  Journal Article
• Funding:
  HHSN266200700005C/AI/NIAID NIH HHS/United States ; HHSN272201400006C/AI/NIAID NIH HHS/United States
• Volume:
  14
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4a5e4185c98edba124d21a440c248a806d0c2f0159bdd96fa8a0bc83e4007875
• Download URL:
  https://stacks.cdc.gov/view/cdc/89353/cdc_89353_DS1.pdf
• File Type:
  [PDF - 694.20 KB ]