Zika Virus infection and Guillain-Barré syndrome in Northeastern Mexico: A case-control study

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Gongora-Rivera, Fernando ; Grijalva, Israel ; Infante-Valenzuela, Adrian ; Cámara-Lemarroy, Carlos ; Garza-González, Elvira ; Paredes-Cruz, Martin ; Grajales-Muñiz, Concepción ; Guerrero-Cantera, José ; Vargas-Ramos, Ignacio ; Soares, Jesus ; Abrams, Joseph Y. ; Styczynski, Ashley R. ; Camacho-Ortiz, Adrián ; Villarino, Margarita E. ; Belay, Ermias D. ; Schonberger, Lawrence B. ; Sejvar, James J.
• Corporate Authors:
  GBS HU-IMSS Working Group
• Description:
  Background
  
  Beginning August 2017, we conducted a prospective case-control investigation in Monterrey, Mexico to assess the association between Zika virus (ZIKV) and Guillain-Barré syndrome (GBS).
  
  Methods
  
  For each of 50 GBS case-patients, we enrolled 2–3 afebrile controls (141 controls in total) matched by sex, age group, and presentation to same hospital within 7 days.
  
  Results
  
  PCR results for ZIKV in blood and/or urine were available on all subjects; serum ZIKV IgM antibody for 52% of case-patients and 80% of controls. Subjects were asked about antecedent illness in the two months prior to neurological onset (for case-patients) or interview (for controls). Laboratory evidence of ZIKV infection alone (PCR+ or IgM+) was not significantly different between case-patients and controls (OR: 1.26, 95% CI: 0.45–3.54) but antecedent symptomatic ZIKV infection [a typical ZIKV symptom (rash, joint pain, or conjunctivitis) plus laboratory evidence of ZIKV infection] was higher among case-patients (OR: 12.45, 95% CI: 1.45–106.64). GBS case-patients with laboratory evidence of ZIKV infection were significantly more likely to have had typical ZIKV symptoms than controls with laboratory evidence of ZIKV infection (OR: 17.5, 95% CI: 3.2–96.6). This association remained significant even when only GBS case-patients who were afebrile for 5 days before onset were included in the analysis, (OR 9.57 (95% CI: 1.07 to 85.35).
  
  Conclusions
  
  During ZIKV epidemics, this study indicates that increases in GBS will occur primarily among those with antecedent symptomatic ZIKV.
  
  
• Subjects:
  Adolescent Adult Aged Case-Control Studies Child Child, Preschool Disease Outbreaks Female Guillain-Barre Syndrome Humans Male Middle Aged Prospective Studies Young Adult Zika Virus Zika Virus Infection

  More +
• Source:
  PLoS One. 2020; 15(3)
• Pubmed ID:
  32214354
• Pubmed Central ID:
  PMC7098590
• Document Type:
  Journal Article
• Place as Subject:
  Mexico
• Volume:
  15
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0d8b4a904260a703430acef925d1f7dad2541c531a2384749337546e25b52bc4
• Download URL:
  https://stacks.cdc.gov/view/cdc/89325/cdc_89325_DS1.pdf
• File Type:
  [PDF - 414.52 KB ]