Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors

Tobler, Leslie H.; Cameron, Mark J.; Lanteri, Marion C.; Prince, Harry E.; Danesh, Ali; Persad, Desmond; Lanciotti, Robert S.; Norris, Philip J.; Kelvin, David J.; Busch, Michael P.

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Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors

Supporting Files

Oct 01 2008
By Tobler, Leslie H. ; Cameron, Mark J. ; Lanteri, Marion C. ; ...

File Language:

English

Details

Alternative Title:

J Infect Dis
Personal Author:

Tobler, Leslie H. ; Cameron, Mark J. ; Lanteri, Marion C. ; Prince, Harry E. ; Danesh, Ali ; Persad, Desmond ; Lanciotti, Robert S. ; Norris, Philip J. ; Kelvin, David J. ; Busch, Michael P.
Description:

To understand early host responses controlling West Nile virus (WNV) infection, acutely viremic blood donors, identified by nucleic acid amplification testing, were enrolled and monitored for RNA-clearance and WNV-specific IgM and IgG antibodies. Viral load and chemokine and cytokine assays were performed on serial samples from donors whose index and first follow-up samples tested negative for IgM. A total of 84% of the specimens obtained from viremic donors before IgM/IgG seroconversion demonstrated a decreasing viral load. Levels of interferon (IFN)-alpha were significantly increased before IgM seroconversion, relative to those in control specimens. CXCL10 and CCL2 were significantly elevated in donor specimens obtained before IgM seroconversion, compared with those obtained after IgM seroconversion. These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication.
Subjects:

Acute Disease Adolescent Adult Aged Blood Donors Chemokine CCL2 Chemokine CXCL10 Female Humans Immunity, Innate Interferons Major Articles And Brief Reports Male Middle Aged Viremia West Nile Fever
Source:

J Infect Dis. 2008; 198(7):979-983
Pubmed ID:

18729779
Pubmed Central ID:

PMC7202400
Document Type:

Journal Article
Funding:

HHSN266200400066C/PHS HHS/United States ; R01-CI-000214/CI/NCPDCID CDC HHS/United States
Volume:

198
Issue:

7
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:b2a7a39ac249719630a8d02ab106035e3580a36a05249b96857e1086c9ccfb84
Download URL:

https://stacks.cdc.gov/view/cdc/87731/cdc_87731_DS1.pdf
File Type:

[PDF - 2.46 MB ]

File Language:

English

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