The meninges enhance leukemia survival in cerebral spinal fluid

Basile, Patrick; Jonart, Leslie M.; Ebadi, Maryam; Johnson, Kimberly; Kerfeld, Morgan; Gordon, Peter M.

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The meninges enhance leukemia survival in cerebral spinal fluid

Published Date:

January 12 2020

Source:

Br J Haematol. 189(3):513-517

Language:

English

[PDF-467.02 KB]

Details:

Alternative Title:

Br J Haematol

Personal Author:

Basile, Patrick ; Jonart, Leslie M. ; Ebadi, Maryam ; Johnson, Kimberly ; Kerfeld, Morgan ; ... More ▼

Description:

Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein, we showed that leukaemia cells exhibit decreased proliferation, elevated reactive oxygen species (ROS) and increased cell death in cerebral spinal fluid (CSF) both in vitro and in vivo. However, interactions between leukaemia and meningeal cells mitigated these adverse effects. This work expands our understanding of the pathophysiology of CNS leukaemia and suggests novel therapeutic approaches for more effectively targeting leukaemia cells in the CNS.

Subject:

[+]

Pubmed ID:

31930492

Pubmed Central ID:

PMC7192757

Document Type:

Journal Article

Funding:

Childrenɹs Cancer Research Fund/International ; T32 CA099936/CA/NCI NIH HHS/United States ; Timothy O'Connell Foundation/International ; American Cancer Society Institutional Research/International ; U50 DP424071/DP/NCCDPHP CDC HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

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	NIHMS1054966-supplement-supp_info.pdf	application/pdf

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The meninges enhance leukemia survival in cerebral spinal fluid

The meninges enhance leukemia survival in cerebral spinal fluid

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