Details:

Alternative Title:
Br J Haematol
Personal Author:
Basile, Patrick ; Jonart, Leslie M. ; Ebadi, Maryam ; Johnson, Kimberly ; Kerfeld, Morgan ; ... More +
Basile, Patrick ; Jonart, Leslie M. ; Ebadi, Maryam ; Johnson, Kimberly ; Kerfeld, Morgan ; Gordon, Peter M. Less -
Description:
Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein, we showed that leukaemia cells exhibit decreased proliferation, elevated reactive oxygen species (ROS) and increased cell death in cerebral spinal fluid (CSF) both in vitro and in vivo. However, interactions between leukaemia and meningeal cells mitigated these adverse effects. This work expands our understanding of the pathophysiology of CNS leukaemia and suggests novel therapeutic approaches for more effectively targeting leukaemia cells in the CNS.
Subjects:
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Acute Lymphpoblastic Leukemia (ALL) Article Cell Adhesion Cell Death Central Nervous System (CNS) Cerebral Spinal Fluid (CSF) Humans Meninges Precursor Cell Lymphoblastic Leukemia-Lymphoma Survival Analysis
Source:
Br J Haematol. 189(3):513-517
Pubmed ID:
31930492
Pubmed Central ID:
PMC7192757
Document Type:
Journal Article
Funding:
Childrenɹs Cancer Research Fund/International ; T32 CA099936/CA/NCI NIH HHS/United States ; Timothy O'Connell Foundation/International ; American Cancer Society Institutional Research/International ; U50 DP424071/DP/NCCDPHP CDC HHS/United States
Childrenɹs Cancer Research Fund/International ; T32 CA099936/CA/NCI NIH HHS/United States ; Timothy O'Connell Foundation/International ; American Cancer Society Institutional Research/International ; U50 DP424071/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8320844dab634560e0ad98eb1c8704b6bc4d991eb0f857163ce1a760bf2d24f6
Download URL:
https://stacks.cdc.gov/view/cdc/87459/cdc_87459_DS1.pdf
File Type:

Supporting Files

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