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LC-MS/MS Analysis of Sugars, Alditols, and Humectants in Smokeless Tobacco Products

Supporting Files
File Language:
English


Details

  • Journal Article:
    Beitr Tab Int
  • Personal Author:
    Wang, Liqun ; Stanfill, Stephen ; Valentin-Blasini, Liza ; Watson, Clifford H. ; Bravo Cardenas, Roberto
  • Description:
    Globally, smokeless tobacco (ST) includes a wide array of chemically diverse products generally used in the oral cavity. Although ST has been widely investigated, this study was undertaken to determine the levels of sugars (mono- and di-saccharides), alditols, and humectants present in major ST categories/subcategories by using high performance liquid chromatography coupled with a triple quadrupole mass spectrometer (HPLC-MS/MS). The products studied included chewing tobacco (loose leaf, plug, twist), US moist snuff, Swedish snus, creamy snuff, dry snuff, dissolvable tobacco products, and tobacco-coated toothpicks. The highest mean sugar level was detected in chewing tobacco (9.3-27.5%, |), followed by dissolvable tobacco (2.1%); all other products were lower than 1%. Creamy snuff had the highest mean alditol levels (22.6%), followed by dissolvable tobacco (15.4%); all others had levels lower than 1%. The detected mean humectant levels ranged from non-detectable to 5.9%. This study demonstrates the broad chemical diversity among ST. This research may aid researchers and public health advocates investigating the exposures and risks of ST. Beitr. Tabakforsch. Int. 28 (2019) 203-213.
  • Subjects:
  • Source:
    Beitr Tab Int. 28(5):203-213
  • DOI:
    http://dx.doi.org/10.2478/cttr-2019-0001
  • Pubmed ID:
    32327867
  • Pubmed Central ID:
    PMC7179048
  • Document Type:
    Text ; Journal Article
  • Funding:
    CC999999/ImCDC/Intramural CDC HHS/United States
  • Genre:
    Journal Article
  • Volume:
    28
  • Issue:
    5
  • Download URL:
    https://stacks.cdc.gov/view/cdc/87317/cdc_87317_DS1.pdf
  • File Type:
    Filetype[PDF - 974.03 KB]
  • Collection(s):
    CDC Public Access
  • Main Document Checksum:
    urn:sha-512:9eb3637faa27766598b63553e22857bc3ca84869eb74c8818b339ba07d178360d3ba7657d0e0ba967ab837f766c68072afdfab3d411f3ae836c88c94063568ae
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