LC-MS/MS Analysis of Sugars, Alditols, and Humectants in Smokeless Tobacco Products

Details

• Alternative Title:
  Beitr Tab Int
• Personal Author:
  Wang, Liqun ; Stanfill, Stephen ; Valentin-Blasini, Liza ; Watson, Clifford H. ; Bravo Cardenas, Roberto
• Description:
  Globally, smokeless tobacco (ST) includes a wide array of chemically diverse products generally used in the oral cavity. Although ST has been widely investigated, this study was undertaken to determine the levels of sugars (mono- and di-saccharides), alditols, and humectants present in major ST categories/subcategories by using high performance liquid chromatography coupled with a triple quadrupole mass spectrometer (HPLC-MS/MS). The products studied included chewing tobacco (loose leaf, plug, twist), US moist snuff, Swedish snus, creamy snuff, dry snuff, dissolvable tobacco products, and tobacco-coated toothpicks. The highest mean sugar level was detected in chewing tobacco (9.3-27.5%, |), followed by dissolvable tobacco (2.1%); all other products were lower than 1%. Creamy snuff had the highest mean alditol levels (22.6%), followed by dissolvable tobacco (15.4%); all others had levels lower than 1%. The detected mean humectant levels ranged from non-detectable to 5.9%. This study demonstrates the broad chemical diversity among ST. This research may aid researchers and public health advocates investigating the exposures and risks of ST. [Beitr. Tabakforsch. Int. 28 (2019) 203-213].
• Subjects:
  Alditol Article Chewing Tobacco Creamy Snuff Dissolvable Tobacco Humectant LC-MS/MS Smokeless Tobacco (ST) Snuff Snus Sugar Tobacco Stick

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• Source:
  Beitr Tab Int. 28(5):203-213
• Pubmed ID:
  32327867
• Pubmed Central ID:
  PMC7179048
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  28
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0af27ab758df3f5fa1f756e7fb30643d52c6830e0370c731fee433c873a1e1f5
• Download URL:
  https://stacks.cdc.gov/view/cdc/87317/cdc_87317_DS1.pdf
• File Type:
  [PDF - 974.03 KB ]