Racial/Ethnic Differences in Survival among Gastric Cancer Patients in California: Gastric Cancer Survival by Race

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Klapheke, Amy K. ; Carvajal-Carmona, Luis G. ; Cress, Rosemary D.
• Description:
  Background:
  
  Gastric cancer is an important cause of death among racial/ethnic minorities in the U.S. The objective of this study was to investigate racial disparities in survival among gastric cancer patients within demographic and disease subgroups.
  
  Methods:
  
  Patients diagnosed with invasive epithelial gastric cancer between 2006–2015 were identified from the California Cancer Registry. Cox proportional hazards regression was used to identify factors associated with survival among non-Hispanic whites (NHWs, n=7,475), non-Hispanic blacks (NHBs, n=1,246), Hispanics (n=6,274), and Asians/Pacific Islanders (APIs, n=4,204). Survival was compared across race/ethnicity within subgroups of demographic and disease factors. Five-year relative survival was also calculated within subgroups.
  
  Results:
  
  There were notable differences in patient characteristics by race/ethnicity, but predictors of survival were similar for each group. Overall, APIs (HR=0.83, 95% CI: 0.79, 0.88, p<0.0001) and Hispanics (HR=0.94, 95% CI: 0.90, 0.99, p=0.0104) had better survival than NHWs, but NHBs and NHWs did not have different prognosis (HR=1.06, 95% CI: 0.98, 1.15, p=0.2237). The survival advantage of APIs persisted in nearly every demographic and disease subgroup, but Hispanics and NHBs had similar survival as NHWs in most groups. Race was not a significant predictor of survival among those with public or no insurance and patients with cardia tumors.
  
  Conclusions:
  
  There are some differences in survival by race/ethnicity, but race/ethnicity alone cannot explain disparate outcomes in gastric cancer. Future studies, particularly ones that investigate the role of population-specific etiological factors and molecular tumor profiles, are needed to further understand factors associated with survival.
  
  
• Subjects:
  Adult Aged Ethnicity Female Humans Male Middle Aged Prognosis Racial Groups Stomach Neoplasms Survival Analysis

  More +
• Source:
  Cancer Causes Control. 30(7):687-696
• Pubmed ID:
  31102083
• Pubmed Central ID:
  PMC7172226
• Document Type:
  Journal Article
• Funding:
  NU58DP006344/DP/NCCDPHP CDC HHS/United States ; 110565843382 - 204-2015/Departamento Administrativo de Ciencia, Tecnología e Innovación (CO)/ ; R01 CA223978/CA/NCI NIH HHS/United States ; HHSN261201800015I/CA/NCI NIH HHS/United States ; 160120516/University of Tolima/ ; P30CA093373/National Cancer Institute (US)/ ; HHSN261201800015C/CA/NCI NIH HHS/United States ; R01CA223978/CA/NCI NIH HHS/United States ; U54CA233306/CA/NCI NIH HHS/United States ; HHSN261201800009I/CA/NCI NIH HHS/United States ; HHSN261201800032C/CA/NCI NIH HHS/United States ; P30 CA093373/CA/NCI NIH HHS/United States ; HHSN261201800009C/CA/NCI NIH HHS/United States ; P30ES023513/ES/NIEHS NIH HHS/United States ; R21CA199631/CA/NCI NIH HHS/United States ; 160114/University of Tolima/ ; U54 CA233306/CA/NCI NIH HHS/United States ; HHSN261201800032I/CA/NCI NIH HHS/United States ; R21 CA199631/CA/NCI NIH HHS/United States
• Place as Subject:
  California
• Volume:
  30
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:783c530f4e6b267db20142786022cc4779b1c879bf440b58851e6e322edac5f2
• Download URL:
  https://stacks.cdc.gov/view/cdc/87154/cdc_87154_DS1.pdf
• File Type:
  [PDF - 128.52 KB ]