Two Suspected Worksite or Occupational Cancer Clusters Investigated Using the Cancer Data Registry and Multiple Primary Standardized Incidence Ratios in SEER*Stat—Idaho, 2013–2014

Details

• Alternative Title:
  J Registry Manag
• Personal Author:
  Rosenthal, Mariana ; Johnson, Christopher J. ; Scoppa, Steve ; Carter, Kris
• Description:
  Background:
  
  Investigations of suspected cancer clusters are resource intensive and rarely identify true clusters: among 428 publicly reported US investigations during 1990–2011, only 1 etiologic cluster was identified. In 2013, the Cancer Data Registry of Idaho (CDRI) was contacted regarding a suspected cancer cluster at a worksite (Cluster A) and among an occupational cohort (Cluster B). We investigated to determine whether these were true clusters.
  
  Methods:
  
  We derived investigation cohorts for Cluster A from facility-provided employee records and for Cluster B from professional licensing records. We used Registry Plus™ Link Plus to conduct probabilistic linkage of cohort members to the CDRI registry and completed matching through manual review by using LexisNexis®, Accurint®, and the Social Security Death Index. We calculated standardized incidence ratios (SIR) using the MP-SIR session type in SEER*Stat and Idaho and US referent populations.
  
  Results:
  
  For Cluster A, we identified 34 cancer cases during 9,689 person-years; compared with Idaho and US rates, 95% CIs for SIRs included 1.0 for 24 of 24 primary site categories. For Cluster B, we identified 78 cancer cases during 15,154 person-years; compared with Idaho rates, 95% CI for SIRs included 1.0 for 23 of 24 primary site categories and was less than 1.0 for lung and bronchus cancers, and compared with US rates, 95% CI for SIRs included 1.0 for 22 of 24 primary site categories and was less than 1.0 for lung and bronchus and colorectal cancers.
  
  Conclusion:
  
  We identified no statistically significant excess in cancer incidence in either cohort. SEER*Stat’s MP-SIR is an efficient tool for performing SIR assessments, a Centers for Disease Control and Prevention/Council of State and Territorial Epidemiologists–recommended step when investigating suspected cancer clusters.
  
  
• Subjects:
  Humans Idaho Incidence Neoplasms Neoplasms, Multiple Primary Registries Workplace
• Keywords:
  Cancer Cancer Registry Cluster Occupational Group Workplace
• Source:
  J Registry Manag. 41(3):128-133
• Pubmed ID:
  28121313
• Pubmed Central ID:
  PMC7147979
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U58 DP003882/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  41
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:36ce9e7efab893316352a9d1b290e436a200780f31eaee36f80cceb46b73fcc6
• Download URL:
  https://stacks.cdc.gov/view/cdc/86799/cdc_86799_DS1.pdf
• File Type:
  [PDF - 111.88 KB ]