Travel surveillance and genomics uncover a hidden Zika outbreak during the waning epidemic

Details

• Alternative Title:
  Cell
• Personal Author:
  Grubaugh, Nathan D. ; Saraf, Sharada ; Gangavarapu, Karthik ; Watts, Alexander ; Tan, Amanda L. ; Oidtman, Rachel J. ; Ladner, Jason T. ; Oliveira, Glenn ; Matteson, Nathaniel L. ; Kraemer, Moritz U.G. ; Vogels, Chantal B.F. ; Hentoff, Aaron ; Bhatia, Deepit ; Stanek, Danielle ; Scott, Blake ; Landis, Vanessa ; Stryker, Ian ; Cone, Marshall R. ; Kopp, Edgar W. ; Cannons, Andrew C. ; Heberlein-Larson, Lea ; White, Stephen ; Gillis, Leah D. ; Ricciardi, Michael J. ; Kwal, Jaclyn ; Lichtenberger, Paola K. ; Magnani, Diogo M. ; Watkins, David I. ; Palacios, Gustavo ; Hamer, Davidson H. ; Gardner, Lauren M. ; Perkins, T. Alex ; Baele, Guy ; Khan, Kamran ; Morrison, Andrea ; Isern, Sharon ; Michael, Scott F. ; Andersen, Kristian G.
• Corporate Authors:
  GeoSentinel Surveillance Network
• Description:
  The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identify transmission not captured by reporting. We uncovered an unreported outbreak in Cuba during 2017, a year after peak transmission in neighboring islands. By sequencing Zika virus, we show that the establishment of the virus was delayed by a year and that the ensuing outbreak was sparked by long-lived lineages of Zika virus from other Caribbean islands. Our data suggest that, although mosquito control in Cuba may initially have been effective at mitigating Zika virus transmission, such measures need to be maintained to be effective. Our study highlights how Zika virus may still be "silently" spreading and provides a framework for understanding outbreak dynamics. VIDEO ABSTRACT.
• Subjects:
  Aedes Animals Cuba Epidemics Genomics Humans Incidence Mosquito Control Phylogeny RNA, Viral Sequence Analysis, RNA Travel West Indies Zika Virus Zika Virus Infection

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• Keywords:
  Clinical Sequencing Genomic Epidemiology Infectious Disease Genomics Phylogenetics Travel Surveillance Zika Virus
• Source:
  Cell. 178(5):1057-1071.e11
• Pubmed ID:
  31442400
• Pubmed Central ID:
  PMC6716374
• Document Type:
  Journal Article
• Funding:
  U50 CK000189/CK/NCEZID CDC HHSUnited States/ ; T32 HD040128/HD/NICHD NIH HHSUnited States/ ; HHSN272201400048C/AI/NIAID NIH HHSUnited States/ ; R01 AI099210/AI/NIAID NIH HHSUnited States/ ; U19 AI135995/AI/NIAID NIH HHSUnited States/ ; R21 AI137690/AI/NIAID NIH HHSUnited States/ ; UL1 TR002550/TR/NCATS NIH HHSUnited States/
• Volume:
  178
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:7cf2186bdddf1167c0fed6119c591247d8cf983e9861afc79f47f69e46f5a089dcf08d03c131804f0419f7b9612b49c0016c3a65e211a0c8b7bdd92c56ed7952
• Download URL:
  https://stacks.cdc.gov/view/cdc/86630/cdc_86630_DS1.pdf
• File Type:
  [PDF - 1.34 MB ]