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Incidence and Progression of Hand Osteoarthritis in a Large Community-Based Cohort: The Johnston County Osteoarthritis Project
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February 19 2020
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Source: Osteoarthritis Cartilage. 28(4):446-452
Details:
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Alternative Title:Osteoarthritis Cartilage
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Personal Author:
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Description:Objective:
To describe the incidence and progression of radiographic and symptomatic hand osteoarthritis (rHOA and sxHOA) in a large community-based cohort.
Design:
Data were from the Johnston County OA Project (1999-2015, 12 ±1.2 years follow-up, age 45+). Participants had bilateral hand radiographs each visit, read for Kellgren-Lawrence grade (KLG) at 30 joints. We defined rHOA as KLG ≥2 in ≥1 joint. SxHOA was defined in a hand/joint with rHOA and self-reported symptoms or tenderness on exam. Incidence was assessed in those without, while progression was assessed in those with, baseline rHOA. Proportions or medians are reported; differences by sex and race were assessed using models appropriate for dichotomous or continuous definitions, additionally adjusted for age, education, BMI, and weight change.
Results:
Of 800 participants (68% women, 32% African American, mean age 60 years), 327 had baseline rHOA and were older, more often white and female, than those without rHOA (n=473). The incidence of HOA was high, for rHOA (60%) and for sxHOA (13%). Women were more likely than men to have incident HOA, particularly for DIP rOA (aOR 1.60 95% CI [1.03, 2.49]) and sxHOA (aOR 2.98 [1.50, 5.91]). Progressive HOA was more similar by sex, although thumb base rOA progressed more frequently in women than in men (aOR 2.56 [1.44, 4.55]). Particularly HOA incidence, but also progression, was more frequent among whites compared with African Americans.
Conclusion:
This study provides much needed information about the natural history of HOA, a common and frequently debilitating condition, in the general population.
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Subjects:
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Source:
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Pubmed ID:32084589
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Pubmed Central ID:PMC7108963
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Document Type:
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Funding:
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Volume:28
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Issue:4
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Main Document Checksum:
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Download URL:
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File Type:
[PDF-431.92 KB]
