Incidence and Progression of Hand Osteoarthritis in a Large Community-Based Cohort: The Johnston County Osteoarthritis Project

Details

• Alternative Title:
  Osteoarthritis Cartilage
• Personal Author:
  Snyder, E. Amanda ; Alvarez, Carolina ; Golightly, Yvonne M. ; Renner, Jordan B. ; Jordan, Joanne M. ; Nelson, Amanda E.
• Description:
  Objective:
  
  To describe the incidence and progression of radiographic and symptomatic hand osteoarthritis (rHOA and sxHOA) in a large community-based cohort.
  
  Design:
  
  Data were from the Johnston County OA Project (1999-2015, 12 ±1.2 years follow-up, age 45+). Participants had bilateral hand radiographs each visit, read for Kellgren-Lawrence grade (KLG) at 30 joints. We defined rHOA as KLG ≥2 in ≥1 joint. SxHOA was defined in a hand/joint with rHOA and self-reported symptoms or tenderness on exam. Incidence was assessed in those without, while progression was assessed in those with, baseline rHOA. Proportions or medians are reported; differences by sex and race were assessed using models appropriate for dichotomous or continuous definitions, additionally adjusted for age, education, BMI, and weight change.
  
  Results:
  
  Of 800 participants (68% women, 32% African American, mean age 60 years), 327 had baseline rHOA and were older, more often white and female, than those without rHOA (n=473). The incidence of HOA was high, for rHOA (60%) and for sxHOA (13%). Women were more likely than men to have incident HOA, particularly for DIP rOA (aOR 1.60 95% CI [1.03, 2.49]) and sxHOA (aOR 2.98 [1.50, 5.91]). Progressive HOA was more similar by sex, although thumb base rOA progressed more frequently in women than in men (aOR 2.56 [1.44, 4.55]). Particularly HOA incidence, but also progression, was more frequent among whites compared with African Americans.
  
  Conclusion:
  
  This study provides much needed information about the natural history of HOA, a common and frequently debilitating condition, in the general population.
  
  
• Subjects:
  Article Epidemiology Hand Osteoarthritis Radiographs
• Source:
  Osteoarthritis Cartilage. 28(4):446-452
• Pubmed ID:
  32084589
• Pubmed Central ID:
  PMC7108963
• Document Type:
  Journal Article
• Funding:
  P60 AR049465/AR/NIAMS NIH HHS/United States ; U01 DP006266/DP/NCCDPHP CDC HHS/United States ; P60 AR064166/AR/NIAMS NIH HHS/United States ; U01 DP003206/DP/NCCDPHP CDC HHS/United States ; U01DP003206/ACL/ACL HHS/United States
• Volume:
  28
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2cd49b3d88aa3cfceadc53ffae7054b6232e43fe47ed05c4096ba854d2bd4bab
• Download URL:
  https://stacks.cdc.gov/view/cdc/86265/cdc_86265_DS1.pdf
• File Type:
  [PDF - 431.92 KB ]