Volatile Organic Compounds in Blood as Biomarkers of Exposure to JP-8 Jet Fuel Among US Air Force Personnel

Maule, Alexis L.; Proctor, Susan P.; Blount, Benjamin C.; Chambers, David M.; McClean, Michael D.

doi:10.1097/JOM.0000000000000611

i

Volatile Organic Compounds in Blood as Biomarkers of Exposure to JP-8 Jet Fuel Among US Air Force Personnel

Supporting Files

1 2016
By Maule, Alexis L. ; Proctor, Susan P. ; Blount, Benjamin C. ; ...

File Language:

English

Details

Alternative Title:

J Occup Environ Med
Personal Author:

Maule, Alexis L. ; Proctor, Susan P. ; Blount, Benjamin C. ; Chambers, David M. ; McClean, Michael D.
Description:

Objective:

This study aimed to evaluate blood volatile organic compound (VOC) levels as biomarkers of occupational jet propulsion fuel 8 (JP-8) exposure while controlling for smoking.

Methods:

Among 69 Air Force personnel, post-shift blood samples were analyzed for components of JP-8, including ethylbenzene, toluene, o-xylene, and m/p-xylene, and for the smoking biomarker, 2,5-dimethylfuran. JP-8 exposure was characterized based on self-report and measured work shift levels of total hydrocarbons in personal air. Multivariate regression was used to evaluate the relationship between JP-8 exposure and post-shift blood VOCs while controlling for potential confounding from smoking.

Results:

Blood VOC concentrations were higher among US Air Force personnel who reported JP-8 exposure and work shift smoking. Breathing zone total hydrocarbons was a significant predictor of VOC blood levels, after controlling for smoking.

Conclusions:

These findings support the use of blood VOCs as a biomarker of occupational JP-8 exposure.
Subjects:

Adolescent Adult Aerospace Medicine Air Pollutants, Occupational Benzene Derivatives Biomarkers Female Humans Hydrocarbons Male Military Personnel Occupational Exposure Toluene Volatile Organic Compounds Xylenes Young Adult
Source:

J Occup Environ Med. 58(1):24-29
Pubmed ID:

26716845
Pubmed Central ID:

PMC7087458
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Volume:

58
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:94cbd899e88ee7d24b41334b43f65ac77a35ee9667178c2393571b38cdabb267
Download URL:

https://stacks.cdc.gov/view/cdc/86100/cdc_86100_DS1.pdf
File Type:

[PDF - 419.12 KB ]

File Language:

English

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