Details:

Alternative Title:
J Gen Virol
Personal Author:
Kayiwa, John Timothy ; Nankya, Annet Martha ; Ataliba, Irene Joyce ; Mossel, Eric C. ; Crabtree, Mary B. ; ... More +
Kayiwa, John Timothy ; Nankya, Annet Martha ; Ataliba, Irene Joyce ; Mossel, Eric C. ; Crabtree, Mary B. ; Lutwama, Julius Julian Less -
Description:
Zika virus (ZIKV), transmitted by Aedes species mosquitoes, was first isolated in Uganda in 1947. From February 2014 to October 2017, the Uganda Virus Research Institute, in collaboration with the US Centers for Diseases Control and Prevention, conducted arbovirus surveillance in acute febrile illness (AFI) patients at St Francis hospital in Nkonkonjeru. Three hundred and eighty-four serum samples were collected and tested for IgM antibodies to yellow fever virus (YFV), West Nile virus (WNV), dengue virus (DENV), chikungunya virus (CHIKV) and ZIKV. Of the 384 samples, 5 were positive for ZIKV IgM. Of these five, three were confirmed by plaque reduction neutralization test (PRNT) to be ZIKV infections. Of the remaining two, one was determined to be a non-specific flavivirus infection and one was confirmed to be alphavirus-positive by reverse transcriptase polymerase chain reaction (RT-PCR). This study provides the first evidence of laboratory-confirmed ZIKV infection in Uganda in five decades, and emphasizes the need to enhance sentinel surveillance.
Subject:
[+]
Arbovirus
Article
Confirmation
Hospital-based
Hospitals
Humans
Plaque Reduction Neutralization Test
Sentinel Surveillance
Uganda
Zika Virus
Zika Virus Infection
Sentinel Surveillance
Zika Virus

Source:
J Gen Virol. 99(9):1248-1252
Pubmed ID:
29975185
Pubmed Central ID:
PMC7064273
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a2ec4b2706ee2d4a0a82ee8d7ae3fab57a50600f0709a992c674b7ad205374c1
File Type:

Supporting Files

• 	nihms-1004777.nxml	xml
  	NIHMS1004777-supplement-Supp_table.pdf	pdf

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