Francisella opportunistica sp. nov., isolated from human blood and cerebrospinal fluid

Details

• Alternative Title:
  Int J Syst Evol Microbiol
• Personal Author:
  Dietrich, Elizabeth A. ; Kingry, Luke C. ; Kugeler, Kiersten J. ; Levy, Craig ; Yaglom, Hayley ; Young, John W. ; Mead, Paul S. ; Petersen, Jeannine M.
• Description:
  Two isolates of a Gram-negative, non-spore-forming coccobacillus cultured from the blood and cerebrospinal fluid of immunocompromised patients in the United States were described previously. Biochemical and phylogenetic analyses revealed that they belong to a novel species within the | genus. Here we describe a third isolate of this species, recovered from blood of a febrile patient with renal failure, and formally name the | species. Whole genome comparisons indicated the three isolates display greater than 99.9 % average nucleotide identity (ANI) to each other and are most closely related to the tick endosymbiont |, with only 88.6-88.8 % ANI to the type strain of |. Based on biochemical, metabolic and genomic comparisons, we propose that these three isolates should be recognized as | sp. nov, with the type strain of the species, PA05-1188|, available through the Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSM 107100) and the American Type Culture Collection (ATCC BAA-2974).
• Subjects:
  Bacterial Typing Techniques Base Composition Blood Cerebrospinal Fluid DNA, Bacterial Francisella Genes, Bacterial Humans Phylogeny RNA, Ribosomal, 16S Sequence Analysis, DNA United States

  More +
• Source:
  Int J Syst Evol Microbiol. 70(2):1145-1151
• Pubmed ID:
  31860434
• Pubmed Central ID:
  PMC7056488
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  70
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3c57276eb34b8a9c246d2f73c0ba43379b5615df7ee3f9597c24d84914002535
• Download URL:
  https://stacks.cdc.gov/view/cdc/85623/cdc_85623_DS1.pdf
• File Type:
  [PDF - 1.15 MB ]