Association of Ultraviolet Radiation Exposure with Dermatomyositis in a National Myositis Patient Registry

Details

• Alternative Title:
  Arthritis Care Res (Hoboken)
• Personal Author:
  Parks, Christine G. ; Wilkerson, Jesse ; Rose, Kathryn M. ; Faiq, Abdullah ; Farhadi, Payam Noroozi ; Long, Craig S. ; Bayat, Nastaran ; Brunner, Hermine I. ; Goldberg, Bob ; McGrath, John A. ; Miller, Frederick W. ; Rider, Lisa G.
• Description:
  Objective
  
  Dermatomyositis (DM) has been associated with geospatial differences in ultraviolet (UV) radiation, but the role of individual determinants of UV exposure prior to diagnosis is unknown.
  
  Methods
  
  We analyzed questionnaire data from 1350 adults in a U.S. national myositis registry (638 with DM, 422 polymyositis [PM], and 290 inclusion body myositis [IBM] diagnosed at ages 18–65 years), examining the likelihood of DM compared with PM and IBM diagnosis, in relation to self-reported sunburn history and job- and hobby-related sun exposures in the year prior to diagnosis. We estimated odds ratios (OR) and 95% confidence intervals (CI) using logistic regression adjusted for age, skin tone, and sex, to determine the association of individual UV exposures with DM diagnosis. We also evaluated the proportion of DM by maximum daily ambient UV exposure, based on UV-B erythemal irradiances for participant residence the year prior to diagnosis.
  
  Results
  
  DM was associated with sunburn in the year before diagnosis (two or more sunburns, OR=1.77; 95%CI 1.28, 2.43 vs. PM/IBM; one sunburn OR=1.44; 95%CI 1.06, 1.95) and with having elevated job- or hobby-related sun exposure (high OR=1.64; 95%CI 1.08, 2.49 or moderate exposure OR=1.35; 95%CI 1.02, 1.78 vs. low or no exposure). Ambient UV intensity was associated with DM in females (beta=3.97, P=0.046), but not overall.
  
  Conclusion
  
  Our findings suggest that high or moderate personal exposure to intense sunlight is associated with developing DM compared with other types of myositis. Prospective research on UV exposure as a modifiable risk factor for DM is warranted.
  
  
• Subjects:
  Adolescent Adult Aged Dermatomyositis Female Humans Male Middle Aged Myositis, Inclusion Body Polymyositis Radiation Exposure Registries Spatial Analysis Sunburn Surveys And Questionnaires Ultraviolet Rays Young Adult

  More +
• Source:
  Arthritis Care Res (Hoboken). 72(11):1636-1644
• Pubmed ID:
  31478597
• Pubmed Central ID:
  PMC7051886
• Document Type:
  Journal Article
• Funding:
  H75 DP001743/DP/NCCDPHP CDC HHSUnited States/ ; HHSN273201600011C/ES/NIEHS NIH HHSUnited States/ ; Z99 ES999999/ImNIH/Intramural NIH HHSUnited States/ ; ZIA ES101074-17/ImNIH/Intramural NIH HHSUnited States/
• Place as Subject:
  United States
• Volume:
  72
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a528286068f24088f6f08a6ec1e88cd62a66bdb98258dde2068673d23b6252ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/85541/cdc_85541_DS1.pdf
• File Type:
  [PDF - 497.78 KB ]