Association of Ultraviolet Radiation Exposure with Dermatomyositis in a National Myositis Patient Registry

Details

• Alternative Title:
  Arthritis Care Res (Hoboken)
• Personal Author:
  Parks, Christine G. ; Wilkerson, Jesse ; Rose, Kathryn M. ; Faiq, Abdullah ; Farhadi, Payam Noroozi ; Long, Craig S. ; Bayat, Nastaran ; Brunner, Hermine I. ; Goldberg, Bob ; McGrath, John A. ; Miller, Frederick W. ; Rider, Lisa G.
  More +
• Description:
  Objective ; Dermatomyositis (DM) has been associated with geospatial differences in ultraviolet (UV) radiation, but the role of individual determinants of UV exposure prior to diagnosis is unknown. ; Methods ; We analyzed questionnaire data from 1350 adults in a U.S. national myositis registry (638 with DM, 422 polymyositis PM, and 290 inclusion body myositis IBM diagnosed at ages 18–65 years), examining the likelihood of DM compared with PM and IBM diagnosis, in relation to self-reported sunburn history and job- and hobby-related sun exposures in the year prior to diagnosis. We estimated odds ratios (OR) and 95% confidence intervals (CI) using logistic regression adjusted for age, skin tone, and sex, to determine the association of individual UV exposures with DM diagnosis. We also evaluated the proportion of DM by maximum daily ambient UV exposure, based on UV-B erythemal irradiances for participant residence the year prior to diagnosis. ; Results ; DM was associated with sunburn in the year before diagnosis (two or more sunburns, OR=1.77; 95%CI 1.28, 2.43 vs. PM/IBM; one sunburn OR=1.44; 95%CI 1.06, 1.95) and with having elevated job- or hobby-related sun exposure (high OR=1.64; 95%CI 1.08, 2.49 or moderate exposure OR=1.35; 95%CI 1.02, 1.78 vs. low or no exposure). Ambient UV intensity was associated with DM in females (beta=3.97, P=0.046), but not overall. ; Conclusion ; Our findings suggest that high or moderate personal exposure to intense sunlight is associated with developing DM compared with other types of myositis. Prospective research on UV exposure as a modifiable risk factor for DM is warranted.
• Subjects:
  • Adolescent
  • Adult
  • Aged
  • Dermatomyositis
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myositis, Inclusion Body
  • Polymyositis
  More +
• Source:
  Arthritis Care Res (Hoboken). 72(11):1636-1644
• Pubmed ID:
  31478597
• Pubmed Central ID:
  PMC7051886
• Document Type:
  Journal Article
• Funding:
  H75 DP001743/DP/NCCDPHP CDC HHSUnited States/ ; HHSN273201600011C/ES/NIEHS NIH HHSUnited States/ ; Z99 ES999999/ImNIH/Intramural NIH HHSUnited States/ ; ZIA ES101074-17/ImNIH/Intramural NIH HHSUnited States/
• Place as Subject:
  United States
• Volume:
  72
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/85541/cdc_85541_DS1.pdf
• File Type:
  [PDF - 497.78 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a528286068f24088f6f08a6ec1e88cd62a66bdb98258dde2068673d23b6252ec