Details:

Alternative Title:
Vaccine
Personal Author:
Brandt, Kevin S. ; Gilmore, Robert D. ;
Brandt, Kevin S. ; Gilmore, Robert D. ; Less -
Description:
The Borrelia burgdorferi outer surface membrane proteins BBA65, BBA66, BBA69, BBA70, and BBA73 were tested for their ability to confer protection against B. burgdorferi infection challenge. Mice were immunized with recombinant forms of the proteins singly or in combinations. Following initial protein inoculation and booster injections, seroconversion was confirmed prior to B. burgdorferi challenge by tick bite. Despite mice having high antibody titers for each antigen, no significant protections against the challenge infections were observed. These results demonstrate that these recombinant proteins were not protective and reflects the challenges confronted to identify effective novel vaccine candidates for Lyme disease.
Subject:
[+]
Animals
Antibodies, Bacterial
Antigens, Bacterial
Article
Borrelia Burgdorferi
Female
Immunization
Lyme Borreliosis
Lyme Disease
Mice
Pfam54 Genes
Recombinant Proteins
Ticks
Vaccination

Source:
Vaccine. 35(40):5310-5313 ;
Pubmed ID:
28867507
Pubmed Central ID:
PMC7041491
Document Type:
Journal Article ;
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:6631b66c15b32463830b379d3225ba7f6142c1a076b2d21f4165ded1fe4d279a
File Type:

Supporting Files

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