Atypical Antipsychotic Use during Pregnancy and Birth Defect Risk: National Birth Defects Prevention Study, 1997–2011

Details

• Journal Article:
  Schizophr Res
• Personal Author:
  ANDERSON, Kayla N. ; AILES, Elizabeth C. ; LIND, Jennifer N. ; BROUSSARD, Cheryl S. ; BITSKO, Rebecca H. ; FRIEDMAN, Jan M. ; BOBO, William V. ; REEFHUIS, Jennita ; TINKER, Sarah C.
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Purpose: ; To examine the prevalence of, and factors associated with, atypical antipsychotic use among U.S. pregnant women, and potential associations between early pregnancy atypical antipsychotic use and risk for 14 birth defects. ; Methods: ; We analyzed data from the National Birth Defects Prevention Study (1997–2011), a U.S. population-based case-control study examining risk factors for major structural birth defects. ; Results: ; Atypical antipsychotic use during pregnancy was more common among women with pre-pregnancy obesity, and women who reported illicit drug use before and during pregnancy, smoking during pregnancy, alcohol use during pregnancy, or use of other psychiatric medications during pregnancy. We observed elevated associations (defined as a crude odds ratio cOR ≥2.0) between early pregnancy atypical antipsychotic use and conotruncal heart defects (6 exposed cases; cOR: 2.3, 95% confidence interval CI: 0.9–6.1), and more specifically Tetralogy of Fallot (3 exposed cases; cOR: 2.5, 95% CI: 0.7–8.8), cleft palate (4 exposed cases; cOR: 2.5, 95% CI: 0.8–7.6), anorectal atresia/stenosis (3 exposed cases; cOR: 2.8, 95% CI: 0.8–9.9), and gastroschisis (3 exposed cases; cOR: 2.1, 95% CI: 0.6–7.3). ; Conclusions: ; Our findings support the close clinical monitoring of pregnant women using atypical antipsychotics. Women treated with atypical antipsychotics generally access healthcare services before pregnancy; efforts to reduce correlates of atypical antipsychotic use might improve maternal and infant health in this population.
• Subjects:
  • Abnormalities, Drug-Induced
  • Adult
  • Antipsychotic Agents
  • Case-Control Studies
  • Comorbidity
  • Female
  • Health Surveys
  • Humans
  • Mental Disorders
  • Pregnancy
  More +
• Keywords:
  • antipsychotics
  • birth defects
  • mental health
  • pharmacoepidemiology
  • Naltrexone
  • Buprenorphine
  • Methadone
  • Mortality
  • Treatment
• Source:
  Schizophr Res. 215:81-88
• DOI:
  http://dx.doi.org/10.1016/j.schres.2019.11.019
• Pubmed ID:
  31761471
• Pubmed Central ID:
  PMC7036025
• Document Type:
  Text ; Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; EP-D-18-001/EPA/EPAUnited States/
• Genre:
  Journal Article
• Volume:
  215
• Download URL:
  https://stacks.cdc.gov/view/cdc/85268/cdc_85268_DS1.pdf
• File Type:
  [PDF - 506.22 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:7f0a6d8e25f17046c3f8fa5370ebbbbb9d040c479248742dfbc896d6bdca42a8f5bdffeeac05410660a70b8c11f25280a8eefa625fcf8702b0d9bb3ee5e0a566