Use of Gabapentinoid Medications Among US adults with Cancer, 2005-2015

Details

• Alternative Title:
  Support Care Cancer
• Personal Author:
  Fauer, Alex J. ; Davis, Matthew A. ; Choi, Sung Won ; Wallner, Lauren P. ; Friese, Christopher R.
• Description:
  Background
  
  Gabapentinoid use for cancer-pain control may be problematic, given unclear mechanisms of action and increased concerns for physical dependence. The purpose of this report is to examine trends of gabapentinoid use among US adults with cancer from 2005–2015.
  
  Methods
  
  We conducted a serial, cross-sectional study using data from the Medical Expenditure Panel Survey (MEPS). We performed multiple logistic regression to examine the annual percentages of gabapentinoid users, which were adjusted for age, sex, and US region of residence.
  
  Results
  
  The amount of gabapentinoid prescriptions filled in 2015 was also estimated. The adjusted percentage of gabapentinoid users in 2015 was 5.60% (3.79%, 7.41%), 2.39 times greater than the percentage in 2005 (p < .001). By 2015, the number of gabapentinoid prescriptions had grown to approximately 3.52 million (2.40 million, 4.65 million).
  
  Conclusion
  
  We observed greater than a two-fold increase in the trend of gabapentinoid medication use among US adults with cancer. Investigations on the long-term efficacy of gabapentinoids for complex pain syndromes, and mitigation of risks, is essential to guide informed clinical management and keep patients safe.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Analgesics Cancer Pain Chronic Pain Cross-Sectional Studies Female Gabapentin Humans Male Middle Aged Neoplasms Pain Management Palliative Care Practice Patterns, Physicians' Substance-Related Disorders Surveys And Questionnaires United States Young Adult

  More +
• Keywords:
  Cancer Gabapentin Practice Pattern Supportive Care
• Source:
  Support Care Cancer. 28(1):5-8
• Pubmed ID:
  31650294
• Pubmed Central ID:
  PMC6884691
• Document Type:
  Journal Article
• Funding:
  P30 CA046592/CA/NCI NIH HHSUnited States/ ; T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; 133507-DSCN-19-048-01-SCN/American Cancer Society/ ; P30CA046592/CA/NCI NIH HHSUnited States/
• Volume:
  28
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:432ec413ecaacdcd71cff024aaf97e7064fdc848cdafaab28d6d6324bd07f81363a959c4e9d0024437d5d446bffd16f864c1a0435067e15648b2e762204dd622
• Download URL:
  https://stacks.cdc.gov/view/cdc/84917/cdc_84917_DS1.pdf
• File Type:
  [PDF - 74.44 KB ]