The association between perceived discrimination in midlife and peripheral neuropathy in a population-based cohort of women: the Study of Women’s Health Across the Nation

Details

• Alternative Title:
  Ann Epidemiol
• Personal Author:
  Dusendang, Jennifer R. ; Reeves, Alexis N. ; Karvonen-Gutierrez, Carrie A. ; Herman, William H. ; Ylitalo, Kelly R. ; Harlow, Siobán D.
• Description:
  Purpose
  
  Peripheral neuropathy (PN) is highly prevalent condition with serious sequelae. However, many studies of the condition have been restricted to populations with diabetes, limiting evidence of potential contributing risk factors including salient psychosocial risk factors such as discrimination.
  
  Methods
  
  The longitudinal Study of Women’s Health Across the Nation was used to assess the relationship between perceived discrimination and prevalent peripheral neuropathy in 1,718 racially/ethnically diverse midlife women. We used multivariable logistic regression to determine the association between perceived discrimination (Detroit Area Study Everyday Discrimination Scale) and PN (symptom questionnaire and monofilament testing) and conducted a formal assessment of the mediating effects of body mass index (BMI).
  
  Results
  
  The overall prevalence of PN was 26.1% in the total sample and 40.9% among women with diabetes. Women who reported perceived discrimination had 29% higher odds of PN as compared to women who did not report perceived discrimination (95% confidence interval (CI): 1.01, 1.66). Approximately 30% of the total effect of discrimination on PN was mediated indirectly by BMI.
  
  Conclusions
  
  More research is needed to determine the contributing factors to non-diabetic PN. Additionally findings re-affirm the impact of financial strain, BMI and diabetes as significant correlates of PN and highlight discrimination as an important risk factor.
  
  
• Subjects:
  Aged Body Mass Index Diabetes Mellitus Female Humans Income Longitudinal Studies Middle Aged Perception Peripheral Nervous System Diseases Racism Risk Factors Smoking Socioeconomic Factors United States Women's Health

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• Keywords:
  Buprenorphine Diabetes Discrimination Methadone Midlife Mortality Naltrexone Peripheral Neuropathy SWAN Treatment Women

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• Source:
  Ann Epidemiol. 37:10-16
• Pubmed ID:
  31447292
• Pubmed Central ID:
  PMC6755046
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; P30 DK092926/DK/NIDDK NIH HHSUnited States/ ; U01 AG012554/AG/NIA NIH HHSUnited States/ ; U01 AG012495/AG/NIA NIH HHSUnited States/ ; U01 AG012535/AG/NIA NIH HHSUnited States/ ; U01 AG012553/AG/NIA NIH HHSUnited States/ ; U01 NR004061/NR/NINR NIH HHSUnited States/ ; U01 AG012539/AG/NIA NIH HHSUnited States/ ; U01 AG012546/AG/NIA NIH HHSUnited States/ ; P30 DK020572/DK/NIDDK NIH HHSUnited States/ ; U01 AG012505/AG/NIA NIH HHSUnited States/ ; U01 AG012531/AG/NIA NIH HHSUnited States/ ; U01 AG017719/AG/NIA NIH HHSUnited States/
• Volume:
  37
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:54133499d14e198c622bcf900306bcb1e2a153db94443e3e6018524f7fc66d4679659ecab49d7e4e45312761e0f174fbea37887a679af3ec50d24c2f76566231
• Download URL:
  https://stacks.cdc.gov/view/cdc/84913/cdc_84913_DS1.pdf
• File Type:
  [PDF - 353.94 KB ]