Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells

Ayala-Nunez, Nilda Vanesa; Follain, Gautier; Delalande, François; Hirschler, Aurélie; Partiot, Emma; Hale, Gillian L.; Bollweg, Brigid C.; Roels, Judith; Chazal, Maxime; Bakoa, Florian; Carocci, Margot; Bourdoulous, Sandrine; Faklaris, Orestis; Zaki, Sherif R.; Eckly, Anita; Uring-Lambert, Béatrice; Doussau, Frédéric; Cianferani, Sarah; Carapito, Christine; Jacobs, Frank M. J.; Jouvenet, Nolwenn; Goetz, Jacky G.; Gaudin, Raphael

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Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells

September 27 2019
By Ayala-Nunez, Nilda Vanesa ; Follain, Gautier ; Delalande, François ; ...
Source: Nat Commun. 10

[PDF-4.58 MB]

English

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Alternative Title:

Nat Commun
Personal Author:

Ayala-Nunez, Nilda Vanesa ; Follain, Gautier ; Delalande, François ; Hirschler, Aurélie ; Partiot, Emma ; ... More +

Ayala-Nunez, Nilda Vanesa ; Follain, Gautier ; Delalande, François ; Hirschler, Aurélie ; Partiot, Emma ; Hale, Gillian L. ; Bollweg, Brigid C. ; Roels, Judith ; Chazal, Maxime ; Bakoa, Florian ; Carocci, Margot ; Bourdoulous, Sandrine ; Faklaris, Orestis ; Zaki, Sherif R. ; Eckly, Anita ; Uring-Lambert, Béatrice ; Doussau, Frédéric ; Cianferani, Sarah ; Carapito, Christine ; Jacobs, Frank M. J. ; Jouvenet, Nolwenn ; Goetz, Jacky G. ; Gaudin, Raphael Less -
Description:

Zika virus (ZIKV) invades and persists in the central nervous system (CNS), causing severe neurological diseases. However the virus journey, from the bloodstream to tissues through a mature endothelium, remains unclear. Here, we show that ZIKV-infected monocytes represent suitable carriers for viral dissemination to the CNS using human primary monocytes, cerebral organoids derived from embryonic stem cells, organotypic mouse cerebellar slices, a xenotypic human-zebrafish model, and human fetus brain samples. We find that ZIKV-exposed monocytes exhibit higher expression of adhesion molecules, and higher abilities to attach onto the vessel wall and transmigrate across endothelia. This phenotype is associated to enhanced monocyte-mediated ZIKV dissemination to neural cells. Together, our data show that ZIKV manipulates the monocyte adhesive properties and enhances monocyte transmigration and viral dissemination to neural cells. Monocyte transmigration may represent an important mechanism required for viral tissue invasion and persistence that could be specifically targeted for therapeutic intervention.
Subjects:

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Animals Article Cell Adhesion Cell Adhesion Molecules Cell Survival Central Nervous System Cerebellum Disease Models, Animal Embryonic Stem Cells Endothelium Female Humans Monocytes Neurons Organoids Transendothelial And Transepithelial Migration Zika Virus Zika Virus Infection
Source:

Nat Commun. 10
Pubmed ID:

31562326
Pubmed Central ID:

PMC6764950
Document Type:

Journal Article
Volume:

10
Collection(s):

CDC Public Access
Main Document Checksum:

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urn:sha256:52ca92b84678d6c1376277de67977bb7cbdd49d45d138834e211cd02d6a6a10b
Download URL:

https://stacks.cdc.gov/view/cdc/84227/cdc_84227_DS1.pdf
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