for early diagnosis and prevention

Details

• Alternative Title:
  Transpl Infect Dis
• Personal Author:
  Mortensen, E. ; Hellinger, W. ; Keller, C. ; Cowan, L.S. ; Shaw, T. ; Hwang, S. ; Pegues, D. ; Ahmedov, S. ; Salfinger, M. ; Bower, W.A.
• Description:
  Introduction.
  
  Solid organ transplant recipients have a higher frequency of tuberculosis (TB) than the general population, with mortality rates of approximately 30%. Although donor-derived TB is reported to account for <5% of TB in solid organ transplants, the source of Mycobacterium tuberculosis infection is infrequently determined.
  
  Methods.
  
  We report 3 new cases of pulmonary TB in lung transplant recipients attributed to donor infection, and review the 12 previously reported cases to assess whether cases could have been prevented and whether any cases that might occur in the future could be detected and investigated more quickly. Specifically, we evaluate whether opportunities existed to determine TB risk on the basis of routine donor history, to expedite diagnosis through routine mycobacterial smears and cultures of respiratory specimens early post transplant, and to utilize molecular tools to investigate infection sources epidemiologically.
  
  Findings.
  
  On review, donor TB risk was present among 7 cases. Routine smears and cultures diagnosed 4 asymptomatic cases. Genotyping was used to support epidemiologic findings in 6 cases.
  
  Conclusion.
  
  Validated screening protocols, including microbiological testing and newer technologies (e.g., interferon-gamma release assays) to identify unrecognized M. tuberculosis infection in deceased donors, are warranted.
  
  
• Subjects:
  Antitubercular Agents Article Donor Selection Early Diagnosis Female Humans Interferon-gamma Release Tests Interferon Gamma Release Assay Lung Transplantation Male Middle Aged Mycobacterium Tuberculosis Transplants Tuberculosis, Pulmonary

  More +
• Source:
  Transpl Infect Dis. 16(1):67-75
• Pubmed ID:
  24383414
• Pubmed Central ID:
  PMC6951793
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  16
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e85a9aee3d588529988632d2fe3d65cc05b7b8e5c674e77fb8053f52e0276304
• Download URL:
  https://stacks.cdc.gov/view/cdc/84119/cdc_84119_DS1.pdf
• File Type:
  [PDF - 83.56 KB ]