Familial Creutzfeldt-Jakob Disease Cluster Among an African American Family

Details

• Alternative Title:
  J Public Health Manag Pract
• Personal Author:
  Johnson, Matthew G. ; Bradley, Kristy K. ; Coffman, Rebecca L. ; Belay, Ermias D.
• Description:
  Familial Creutzfeldt-Jakob disease (fCJD) results from inheritance of mutations in the prion protein gene. Confirming fCJD diagnosis is essential for informing persons of their potential hereditary risk and for genetic counseling to support personal decisions for genetic testing and family planning. We describe a case of fCJD that was linked to a large cluster of African Americans with fCJD identified through a public health investigation, including 8 confirmed cases and 13 suspected cases involving 7 generations in 1 family. Genetic counseling is an important component of fCJD management for families coping with genetic prion diseases.
• Subjects:
  Black Or African American Cluster Analysis Creutzfeldt-Jakob Syndrome Genetic Testing Humans Prions Public Health
• Source:
  J Public Health Manag Pract. 23(6):614-617
• Pubmed ID:
  27997483
• Pubmed Central ID:
  PMC6947528
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  23
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9b4aa379b678adf8e5c35ec1d887fa3ff2deca5363a14ac1f3175d63b8032c38
• Download URL:
  https://stacks.cdc.gov/view/cdc/84104/cdc_84104_DS1.pdf
• File Type:
  [PDF - 186.45 KB ]