Ambient air pollution, asthma drug response, and telomere length in African American youth

Details

• Alternative Title:
  J Allergy Clin Immunol
• Personal Author:
  Lee, Eunice Y. ; Oh, Sam S. ; White, Marquitta J. ; Eng, Celeste S. ; Elhawary, Jennifer R. ; Borrell, Luisa N. ; Nuckton, Thomas J. ; Zeiger, Andrew M. ; Keys, Kevin L. ; Mak, Angel C. Y. ; Hu, Donglei ; Huntsman, Scott ; Contreras, Maria G. ; Samedy, Lesly-Anne ; Goddard, Pagé C. ; Salazar, Sandra L. ; Brigino-Buenaventura, Emerita N. ; Davis, Adam ; Meade, Kelley E. ; LeNoir, Michael A. ; Lurmann, Fred W. ; Burchard, Esteban G. ; Eisen, Ellen A. ; Balmes, John R.
• Description:
  Background:
  
  Telomere length (TL) can serve as a potential biomarker for conditions associated with chronic oxidative stress and inflammation, such as asthma. Air pollution can induce oxidative stress. Understanding the relationship between TL, asthma, and air pollution is important for identifying risk factors contributing to unhealthy aging in children. Objectives: We sought to investigate associations between exposures to ambient air pollutants and TL in African American children and adolescents and to examine whether African ancestry, asthma status, and steroid medication use alter the association.
  
  Methods:
  
  Linear regression was used to examine associations between absolute telomere length (aTL) and estimated annual average residential ozone (O3) and fine particulate matter with a diameter of 2.5 μm or less (PM2.5) exposures in a cross-sectional analysis of 1072 children in an existing asthma case-control study. African ancestry, asthma status, and use of steroid medications were examined as effect modifiers.
  
  Results:
  
  Participants’ aTLs were measured by using quantitative PCR. A 1-ppb and 1 μg/m3 increase in annual average exposure to O3 and PM2.5 were associated with a decrease in aTL of 37.1 kilo-base pair (kb; 95% CI, −66.7 to −7.4 kb) and 57.1 kb (95% CI, −118.1 to 3.9 kb), respectively. African ancestry and asthma were not effect modifiers; however, exposure to steroid medications modified the relationships between TL and pollutants. Past-year exposure to O3 and PM2.5 was associated with shorter TLs in patients without steroid use.
  
  Conclusion:
  
  Exposure to air pollution was associated with shorter TLs in nonasthmatic children and adolescents. This was not the case for asthmatic children as a group, but those receiving steroid medication had less shortening than those not using steroids. Reduced exposure to air pollution in childhood might help to preserve TL.
  
  
• Subjects:
  Adolescent Adult Air Pollutants Air Pollution Asthma Black Or African American Child Environmental Exposure Humans Ozone Particulate Matter Steroids Telomere Young Adult

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• Keywords:
  Asthma Buprenorphine Children Fine Particulate Matter With A Diameter Of 2.5 μm Or Less Methadone Minority Mortality Naltrexone Telomeres Treatment
• Source:
  J Allergy Clin Immunol. 144(3):839-845.e10
• Pubmed ID:
  31247265
• Pubmed Central ID:
  PMC6938647
• Document Type:
  Journal Article
• Funding:
  R01 HL141992/HL/NHLBI NIH HHSUnited States/ ; R01 GM075316/GM/NIGMS NIH HHSUnited States/ ; K01 HL140218/HL/NHLBI NIH HHSUnited States/ ; T32 HG000044/HG/NHGRI NIH HHSUnited States/ ; R01 HL128439/HL/NHLBI NIH HHSUnited States/ ; R01 HL117004/HL/NHLBI NIH HHSUnited States/ ; R21 ES024844/ES/NIEHS NIH HHSUnited States/ ; R01 ES015794/ES/NIEHS NIH HHSUnited States/ ; T42 OH008429/OH/NIOSH CDC HHSUnited States/ ; R01 HL135156/HL/NHLBI NIH HHSUnited States/ ; T32 GM007546/GM/NIGMS NIH HHSUnited States/ ; RL5 GM118984/GM/NIGMS NIH HHSUnited States/ ; R01 MD010443/MD/NIMHD NIH HHSUnited States/
• Volume:
  144
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:765668ae74d5c15b0fe36360f2264b6c6c22ba474aeb7da7a4d13614746b243a9adcab728100b49d6ef3681e83b59a620467d226e0981012ded5c30653148830
• Download URL:
  https://stacks.cdc.gov/view/cdc/83988/cdc_83988_DS1.pdf
• File Type:
  [PDF - 407.92 KB ]