A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele

Abrams, A. Jeanine; Kirkcaldy, Robert D.; Pettus, Kevin; Fox, Jan L.; Kubin, Grace; Trees, David L.

doi:10.1097/OLQ.0000000000000645

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A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele

August 2017
By Abrams, A. Jeanine ; Kirkcaldy, Robert D. ; Pettus, Kevin ; ...
http://dx.doi.org/10.1097/OLQ.0000000000000645
Source: Sex Transm Dis. 44(8):492-494

[PDF-288.69 KB]

English

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Details:

Alternative Title:

Sex Transm Dis
Personal Author:

Abrams, A. Jeanine ; Kirkcaldy, Robert D. ; Pettus, Kevin ; Fox, Jan L. ; Kubin, Grace ; ... More +

Abrams, A. Jeanine ; Kirkcaldy, Robert D. ; Pettus, Kevin ; Fox, Jan L. ; Kubin, Grace ; Trees, David L. Less -
Description:

We report a case of Neisseria gonorrhoeae with a non-mosaic penA allele that exhibited decreased susceptibility to extended-spectrum cephalosporins, including a ceftriaxone minimum inhibitory concentration of 0.5 μg/mL. An analysis of resistance determinants suggested that the observed phenotype might have resulted from the combined effects of mutations in multiple genes.
Subjects:

[+]

Adult Alleles Anti-Bacterial Agents Article Carrier Proteins Ceftriaxone Drug Resistance, Bacterial Gonorrhea Humans Male Microbial Sensitivity Tests Mutation Neisseria Gonorrhoeae Phenotype Serine-Type D-Ala-D-Ala Carboxypeptidase Urethra Urethritis
Source:

Sex Transm Dis. 44(8):492-494
Pubmed ID:

28703729
Pubmed Central ID:

PMC6932624
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHS/United States
Volume:

44
Issue:

8
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:ee6b69f311a459a7f87b656b23357580ec6a6a6b8446d5a0c7caf93e42749308
Download URL:

https://stacks.cdc.gov/view/cdc/83775/cdc_83775_DS1.pdf
File Type:

nihms-1062132.nxml

xml

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