Proficiency Testing of Viral Marker Screening in African Blood Centers — Seven African Countries, 2017

Drammeh, Bakary; Laperche, Syria; Hilton, Joan F.; Kaidarova, Zhanna; Ozeryansky, Larisa; De, Anindya; Kalou, Mireille; Benech, Irene; Parekh, Bharat; Murphy, Edward L.; Abdallah, Zaituni; Abdikadir, Abby; Abjah, Usman Ali Medugu; Adegbamigbe, Oluwafemi; Adeleke, Victoria; Adeyeye, Lara; Agba, Janet; Ajala, Stephen; Allotey, Sheila; Bacheyie, Peter Paul; Banda, Patrick; Barnabas, Obasi; Bassey, Oriji O.; Bila, Diocleciano; Bonsu, Frank; Caparros, Remi; Chelimo, Aglean; Chilambula, Charles; Chinkango, Lameck; Chongo, Armando; Chongola, Francelino Luciano; Chuka, Onyeka Paul; Cobbson, Samuel; Desousa, Leonardo; Dogbe, Elliot Eli; Domingos, Augusto; Ebomwonyi, Vanetine; Elisha, Rumji; Escova, Joanisse Samuel; Fideliz, Esperança; Gwamna, Jerry; Haule, Dunstan; Hindes, Daniel; Ismail, Tehreen; Jemusse, Rui Labissone; João, Alberto; Kaba, Muluken; Kabolile, Nasibu; Kibet, Zachary; Kihara, Sammy; Kilowoko, Basilius; Kimani, Daniel; Kimanzi, Steve; Kimamo, Martha; Kinyaha, Richard; Kiptanui, Nick; Kithi, Khamisi; Koech, Festus; Kunyenga, Steve; Kyando, Yusto; Lawrence, Alexander; Limited, Chimwemwe; Lucio, Jorge; Manu, Simon; Mattunda, Sylvester; Mbarak,, Nassim; Mbaya, Bridon; Mbui, Alice; Mdenyo, Japheth; Mengwa, Rodgers MC; Meribe, Chidozie; Mfune, Thom; Michael, Onoja; Muria, Fernando José; Mwamtobe, Andrew; Mwamzuka, Musa; Mwangi, Christina; Mwenebanda, Deeps; Mungai, Allan; Mungai, Antony; Muhsin, Jabir; Mwajombe, Venantia; Mwiyuma, Charles; Nani, Emmanuel; Ndaki, Henry; Ndahiriwe, Olivier; Ndhlovu, Daniel; Nditi, Macrina; Neves, Miguel; Ngwira, Eviness; Nkrumah, Bernard; Nzioka, Peter; Odiabara, Kingsley; Odthiambo, Elizabeth; Ojo, Omo T.; Okoye, McPaul; Okyere, Mavis; Oluyemisi, Ogunkola; Owusu-Ansah, Anthony; Provinseh, John; Rotich, Thomas; Saasi, Razak; Sabaya, Simon; Sabonete, Tinache Gabriel; Sam, Yaw; Sani, Ibrahim; Sunday, Bamidele; Tarimo, Priscilla; Tolulope, Adekoya Benson; Torokaa, Peter; Towo, Ndeonasia; Umoru, Erlinda; Victorino, Jose; Wuor, Kingsley; Yelima, James; Yohanna, Samuila

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Proficiency Testing of Viral Marker Screening in African Blood Centers — Seven African Countries, 2017

October 25 2019
By Drammeh, Bakary ; Laperche, Syria ; Hilton, Joan F. ; ...
Source: MMWR Morb Mortal Wkly Rep. 68(42):947-952

[PDF-155.45 KB]

English

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Details:

Alternative Title:

MMWR Morb Mortal Wkly Rep
Personal Author:

Drammeh, Bakary ; Laperche, Syria ; Hilton, Joan F. ; Kaidarova, Zhanna ; Ozeryansky, Larisa ; ... More +

Drammeh, Bakary ; Laperche, Syria ; Hilton, Joan F. ; Kaidarova, Zhanna ; Ozeryansky, Larisa ; De, Anindya ; Kalou, Mireille ; Benech, Irene ; Parekh, Bharat ; Murphy, Edward L. ; Abdallah, Zaituni ; Abdikadir, Abby ; Abjah, Usman Ali Medugu ; Adegbamigbe, Oluwafemi ; Adeleke, Victoria ; Adeyeye, Lara ; Agba, Janet ; Ajala, Stephen ; Allotey, Sheila ; Bacheyie, Peter Paul ; Banda, Patrick ; Barnabas, Obasi ; Bassey, Oriji O. ; Bila, Diocleciano ; Bonsu, Frank ; Caparros, Remi ; Chelimo, Aglean ; Chilambula, Charles ; Chinkango, Lameck ; Chongo, Armando ; Chongola, Francelino Luciano ; Chuka, Onyeka Paul ; Cobbson, Samuel ; Desousa, Leonardo ; Dogbe, Elliot Eli ; Domingos, Augusto ; Ebomwonyi, Vanetine ; Elisha, Rumji ; Escova, Joanisse Samuel ; Fideliz, Esperança ; Gwamna, Jerry ; Haule, Dunstan ; Hindes, Daniel ; Ismail, Tehreen ; Jemusse, Rui Labissone ; João, Alberto ; Kaba, Muluken ; Kabolile, Nasibu ; Kibet, Zachary ; Kihara, Sammy ; Kilowoko, Basilius ; Kimani, Daniel ; Kimanzi, Steve ; Kimamo, Martha ; Kinyaha, Richard ; Kiptanui, Nick ; Kithi, Khamisi ; Koech, Festus ; Kunyenga, Steve ; Kyando, Yusto ; Lawrence, Alexander ; Limited, Chimwemwe ; Lucio, Jorge ; Manu, Simon ; Mattunda, Sylvester ; Mbarak,, Nassim ; Mbaya, Bridon ; Mbui, Alice ; Mdenyo, Japheth ; Mengwa, Rodgers MC ; Meribe, Chidozie ; Mfune, Thom ; Michael, Onoja ; Muria, Fernando José ; Mwamtobe, Andrew ; Mwamzuka, Musa ; Mwangi, Christina ; Mwenebanda, Deeps ; Mungai, Allan ; Mungai, Antony ; Muhsin, Jabir ; Mwajombe, Venantia ; Mwiyuma, Charles ; Nani, Emmanuel ; Ndaki, Henry ; Ndahiriwe, Olivier ; Ndhlovu, Daniel ; Nditi, Macrina ; Neves, Miguel ; Ngwira, Eviness ; Nkrumah, Bernard ; Nzioka, Peter ; Odiabara, Kingsley ; Odthiambo, Elizabeth ; Ojo, Omo T. ; Okoye, McPaul ; Okyere, Mavis ; Oluyemisi, Ogunkola ; Owusu-Ansah, Anthony ; Provinseh, John ; Rotich, Thomas ; Saasi, Razak ; Sabaya, Simon ; Sabonete, Tinache Gabriel ; Sam, Yaw ; Sani, Ibrahim ; Sunday, Bamidele ; Tarimo, Priscilla ; Tolulope, Adekoya Benson ; Torokaa, Peter ; Towo, Ndeonasia ; Umoru, Erlinda ; Victorino, Jose ; Wuor, Kingsley ; Yelima, James ; Yohanna, Samuila Less -
Corporate Authors:

CDC Proficiency Testing Study Group
Description:

A 2014 report evaluating accuracy of serologic tTesting for transfusion-transmissible Viruses at African blood center laboratories found sensitivities of 92%, 87%, and 90% for detecting infections with human immunodeficiency Virus (HIV), hepatitis B Virus (HBV), and hepatitis C Virus (HCV), respectively (1). Following substantial investments in national blood transfusion service (NBTS) laboratories, in 2017 investigators tested proficiency at 84 blood center laboratories (29 NBTS and 55 non-NBTS) in seven African countries. A blinded panel of 25 plasma samples was shipped to each participating laboratory for tTesting with their usual protocols based on rapid diagnostic tests (RDTs) (2) and third and fourth generation enzyme immunoassays (EIA-3 and EIA-4). Sensitivity and specificity were estimated using separate regression models that clustered assays by laboratory and adjusted for assay type and NBTS laboratory status. Mean specificities were ≥95% for all three Viruses; however, mean sensitivities were 97% for HIV-positive, 76% for HBV-positive, and 80% for HCV-positive samples. Testing sensitivities for all Viruses were high when EIA-3 assays were used (≥97%). Lower sensitivities for HBV-positive samples and HCV-positive samples were associated with assay types other than EIA-3, used primarily by non-NBTS laboratories. Proficiency for HIV tTesting has improved following international investments, but proficiency remains suboptimal for HBV and HCV tTesting. In sub-Saharan African blood centers, the quality of rapid tests used for HBV and HCV screening needs to be improved or their use discouraged in favor of EIA-3 tests.
Subjects:

[+]

Blood Banks Diagnostic Tests, Routine Full Report HepaciVirus Hepatitis B Virus HIV Humans Immunoenzyme Techniques Mass Screening Sensitivity And Specificity Serologic Tests
Source:

MMWR Morb Mortal Wkly Rep. 68(42):947-952
Pubmed ID:

31652252
Pubmed Central ID:

PMC6812837
Document Type:

Journal Article
Place as Subject:

Ghana ; Kenya ; Malawi ; Mozambique ; Nigeria ; ... More +

Ghana ; Kenya ; Malawi ; Mozambique ; Nigeria ; Rwanda ; Tanzania Less -
Volume:

68
Issue:

42
Collection(s):

Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:

[+]

urn:sha256:93b31435e2f0bfeb288e169bbc7f14b13db1090e2ae63b1c7bdbbd83f627543d
Download URL:

https://stacks.cdc.gov/view/cdc/83766/cdc_83766_DS1.pdf
File Type:

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