Proficiency Testing of Viral Marker Screening in African Blood Centers — Seven African Countries, 2017

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Drammeh, Bakary ; Laperche, Syria ; Hilton, Joan F. ; Kaidarova, Zhanna ; Ozeryansky, Larisa ; De, Anindya ; Kalou, Mireille ; Benech, Irene ; Parekh, Bharat ; Murphy, Edward L. ; Abdallah, Zaituni ; Abdikadir, Abby ; Abjah, Usman Ali Medugu ; Adegbamigbe, Oluwafemi ; Adeleke, Victoria ; Adeyeye, Lara ; Agba, Janet ; Ajala, Stephen ; Allotey, Sheila ; Bacheyie, Peter Paul ; Banda, Patrick ; Barnabas, Obasi ; Bassey, Oriji O. ; Bila, Diocleciano ; Bonsu, Frank ; Caparros, Remi ; Chelimo, Aglean ; Chilambula, Charles ; Chinkango, Lameck ; Chongo, Armando ; Chongola, Francelino Luciano ; Chuka, Onyeka Paul ; Cobbson, Samuel ; Desousa, Leonardo ; Dogbe, Elliot Eli ; Domingos, Augusto ; Ebomwonyi, Vanetine ; Elisha, Rumji ; Escova, Joanisse Samuel ; Fideliz, Esperança ; Gwamna, Jerry ; Haule, Dunstan ; Hindes, Daniel ; Ismail, Tehreen ; Jemusse, Rui Labissone ; João, Alberto ; Kaba, Muluken ; Kabolile, Nasibu ; Kibet, Zachary ; Kihara, Sammy ; Kilowoko, Basilius ; Kimani, Daniel ; Kimanzi, Steve ; Kimamo, Martha ; Kinyaha, Richard ; Kiptanui, Nick ; Kithi, Khamisi ; Koech, Festus ; Kunyenga, Steve ; Kyando, Yusto ; Lawrence, Alexander ; Limited, Chimwemwe ; Lucio, Jorge ; Manu, Simon ; Mattunda, Sylvester ; Mbarak,, Nassim ; Mbaya, Bridon ; Mbui, Alice ; Mdenyo, Japheth ; Mengwa, Rodgers MC ; Meribe, Chidozie ; Mfune, Thom ; Michael, Onoja ; Muria, Fernando José ; Mwamtobe, Andrew ; Mwamzuka, Musa ; Mwangi, Christina ; Mwenebanda, Deeps ; Mungai, Allan ; Mungai, Antony ; Muhsin, Jabir ; Mwajombe, Venantia ; Mwiyuma, Charles ; Nani, Emmanuel ; Ndaki, Henry ; Ndahiriwe, Olivier ; Ndhlovu, Daniel ; Nditi, Macrina ; Neves, Miguel ; Ngwira, Eviness ; Nkrumah, Bernard ; Nzioka, Peter ; Odiabara, Kingsley ; Odthiambo, Elizabeth ; Ojo, Omo T. ; Okoye, McPaul ; Okyere, Mavis ; Oluyemisi, Ogunkola ; Owusu-Ansah, Anthony ; Provinseh, John ; Rotich, Thomas ; Saasi, Razak ; Sabaya, Simon ; Sabonete, Tinache Gabriel ; Sam, Yaw ; Sani, Ibrahim ; Sunday, Bamidele ; Tarimo, Priscilla ; Tolulope, Adekoya Benson ; Torokaa, Peter ; Towo, Ndeonasia ; Umoru, Erlinda ; Victorino, Jose ; Wuor, Kingsley ; Yelima, James ; Yohanna, Samuila
• Corporate Authors:
  CDC Proficiency Testing Study Group
• Description:
  A 2014 report evaluating accuracy of serologic tTesting for transfusion-transmissible Viruses at African blood center laboratories found sensitivities of 92%, 87%, and 90% for detecting infections with human immunodeficiency Virus (HIV), hepatitis B Virus (HBV), and hepatitis C Virus (HCV), respectively (1). Following substantial investments in national blood transfusion service (NBTS) laboratories, in 2017 investigators tested proficiency at 84 blood center laboratories (29 NBTS and 55 non-NBTS) in seven African countries. A blinded panel of 25 plasma samples was shipped to each participating laboratory for tTesting with their usual protocols based on rapid diagnostic tests (RDTs) (2) and third and fourth generation enzyme immunoassays (EIA-3 and EIA-4). Sensitivity and specificity were estimated using separate regression models that clustered assays by laboratory and adjusted for assay type and NBTS laboratory status. Mean specificities were ≥95% for all three Viruses; however, mean sensitivities were 97% for HIV-positive, 76% for HBV-positive, and 80% for HCV-positive samples. Testing sensitivities for all Viruses were high when EIA-3 assays were used (≥97%). Lower sensitivities for HBV-positive samples and HCV-positive samples were associated with assay types other than EIA-3, used primarily by non-NBTS laboratories. Proficiency for HIV tTesting has improved following international investments, but proficiency remains suboptimal for HBV and HCV tTesting. In sub-Saharan African blood centers, the quality of rapid tests used for HBV and HCV screening needs to be improved or their use discouraged in favor of EIA-3 tests.
• Subjects:
  Blood Banks Diagnostic Tests, Routine Full Report HepaciVirus Hepatitis B Virus HIV Humans Immunoenzyme Techniques Mass Screening Sensitivity And Specificity Serologic Tests

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 68(42):947-952
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  31652252
• Pubmed Central ID:
  PMC6812837
• Document Type:
  Journal Article
• Place as Subject:
  Ghana ; Kenya ; Malawi ; Mozambique ; Nigeria ; Rwanda ; Tanzania
• Pages in Document:
  6 pdf pages
• Volume:
  68
• Issue:
  42
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:b255d29c2e500f5ea09ee7484364ccddb76cf85d8b873cb50462894fb5351413e786a0396513ddb317ec25a1f6279e2f3148e913fbad96612f5e44f60ec5abae
• Download URL:
  https://stacks.cdc.gov/view/cdc/83766/cdc_83766_DS1.pdf
• File Type:
  [PDF - 155.45 KB ]