Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Personal Author:
Whitehouse, Erin R. ; Rao, Agam K. ; Yu, Yon C. ; Yu, Patricia A. ; Griffin, Margaret ; ... More +
Whitehouse, Erin R. ; Rao, Agam K. ; Yu, Yon C. ; Yu, Patricia A. ; Griffin, Margaret ; Gorman, Susan ; Angel, Kristen A. ; McDonald, Eric C. ; Manlutac, Anna Liza ; de Perio, Marie A. ; McCollum, Andrea M. ; Davidson, Whitni ; Wilkins, Kimberly ; Ortega, Eddy ; Satheshkumar, Panayampalli S. ; Townsend, Michael B. ; Isakari, Marcia ; Petersen, Brett W. Less -
Description:
Vaccinia virus (VACV) is an orthopoxvirus used in smallpox vaccines, as a vector for novel cancer treatments, and for experimental vaccine research (1). The Advisory Committee on Immunization Practices (ACIP) recommends smallpox vaccination for laboratory workers who handle replication-competent VACV (1). For bioterrorism preparedness, the U.S. government stockpiles tecovirimat, the first Food and Drug Administration-approved antiviral for treatment of smallpox (caused by variola virus and globally eradicated in 1980*|) (2). Tecovirimat has activity against other orthopoxviruses and can be administered under a CDC investigational new drug protocol. CDC was notified about an unvaccinated laboratory worker with a needlestick exposure to VACV, who developed a lesion on her left index finger. CDC and partners performed laboratory confirmation, contacted the study sponsor to identify the VACV strain, and provided oversight for the first case of laboratory-acquired VACV treated with tecovirimat plus intravenous vaccinia immunoglobulin (VIGIV). This investigation highlights 1) the misconception among laboratory workers about the virulence of VACV strains; 2) the importance of providing laboratorians with pathogen information and postexposure procedures; and 3) that although tecovirimat can be used to treat VACV infections, its therapeutic benefit remains unclear.
Subject:
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Adult
Female
Full Report
Humans
Laboratory Personnel
Needlestick Injuries
Occupational Diseases
Occupational Injuries
Vaccinia

Source:
MMWR Morb Mortal Wkly Rep. 68(42):943-946
Pubmed ID:
31647789
Pubmed Central ID:
PMC6812835
Document Type:
Journal Article
Place as Subject:
California
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
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urn:sha256:54e8e17f4ffd8250191b9479323b88801fb499c51c59444df818c9c2cd52af7e
File Type:

Supporting Files

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