Novel Treatment of a Vaccinia Virus Infection from an Occupational Needlestick — San Diego, California, 2019

Details

• Journal Article:
  Morbidity and Mortality Weekly Report
• Personal Author:
  Whitehouse, Erin R. ; Rao, Agam K. ; Yu, Yon C. ; Yu, Patricia A. ; Griffin, Margaret ; Gorman, Susan ; Angel, Kristen A. ; McDonald, Eric C. ; Manlutac, Anna L. ; de Perio, Marie A. ; McCollum, Andrea M. ; Davidson, Whitni ; Wilkins, Kimberly ; Ortega, Eddy ; Satheshkumar, Panayampalli S. ; Townsend, Michael B. ; Isakari, Marcia ; Petersen, Brett W.
• Description:
  What is already known about this topic? Inadvertent exposure to the virus Vaccinia, an orthopoxvirus used in biomedical research, can cause considerable injury and time lost from work. Vaccination is recommended for laboratorians using replication-competent vaccinia virus; however, laboratories set their own policies. What is added by this report? Tecovirimat, a novel antiviral approved for treatment of smallpox, and vaccinia immunoglobulin were used to safely treat an occupational exposure in an unvaccinated laboratorian who was excluded from work for 4 months. What are the implications for public health practice? Laboratories should ensure that workers are informed of the risks associated with manipulation of vaccinia virus and should counsel workers about the potential benefits of vaccination received according to current guidelines. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Delivery Of Health Care Full Report Hazardous Substances Health Care Facilities Workforce And Services Immune System Laboratories Laboratory Personnel Musculoskeletal System Needlestick Injuries Occupational Diseases Occupational Exposure Occupational Health Occupational Injuries Public Health Risk Assessment Safety Viral Diseases

  More +
• Keywords:
  Viral infections; Employee exposure; Needlestick injuries; Antiviral; Vaccines; Immunizations; Medical care; Medical treatment; Occupational exposure; Medical monitoring; Infection control; Hand injuries; Medical research; Laboratories; Laboratory workers; Injuries; Lost work days; Immunoglobulins; Risk management; Hazard controls; Hazard communication; Guidelines; Public health; Safety practices; Surveillance; Safety education
• Source:
  MMWR 2019 Oct; 68(42):943-946
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195
• Pubmed ID:
  31647789
• Pubmed Central ID:
  PMC6812835
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  4 pdf pages
• Volume:
  68
• Issue:
  42
• NIOSHTIC Number:
  nn:20057574
• Contact Point Address:
  Erin R. Whitehouse, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, CDC
• Email:
  EWhitehouse@cdc.gov
• CAS Registry Number:
  Tecovirimat (CAS RN 869572-92-9)
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Services
• Peer Reviewed:
  False
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR) National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:00ee0ec512d340cf2d02f925a910abccd2f189e2654d48bd881a8817fbceee253c14d4c4df41c1a7a3fdc30836a65414257be96127a689008f35e5fbd24629d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/83765/cdc_83765_DS1.pdf
• File Type:
  [PDF - 125.98 KB ]