Metagenomic signatures of early life hospitalization and antibiotic treatment in the infant gut microbiota and resistome persist long after discharge

Details

• Alternative Title:
  Nat Microbiol
• Personal Author:
  Gasparrini, Andrew J. ; Wang, Bin ; Sun, Xiaoqing ; Kennedy, Elizabeth A. ; Hernandez-Leyva, Ariel ; Ndao, I. Malick ; Tarr, Phillip I. ; Warner, Barbara B. ; Dantas, Gautam
• Description:
  Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics because they are vulnerable to infection. It is not known whether the short-term effects of antibiotics on the preterm infant gut microbiota and resistome persist after discharge from neonatal intensive care units. Here, we use complementary metagenomic, culture-based and machine learning techniques to study the gut microbiota and resistome of antibiotic-exposed preterm infants during and after hospitalization, and we compare these readouts to antibiotic-naive healthy infants sampled synchronously. We find a persistently enriched gastrointestinal antibiotic resistome, prolonged carriage of multidrug-resistant Enterobacteriaceae and distinct antibiotic-driven patterns of microbiota and resistome assembly in extremely preterm infants that received early-life antibiotics. The collateral damage of early-life antibiotic treatment and hospitalization in preterm infants is long lasting. We urge the development of strategies to reduce these consequences in highly vulnerable neonatal populations.
• Subjects:
  Article
• Source:
  Nat Microbiol. 4(12):2285-2297
• Pubmed ID:
  31501537
• Pubmed Central ID:
  PMC6879825
• Document Type:
  Journal Article
• Funding:
  R01 GM099538/GM/NIGMS NIH HHS/United States ; T32 DK077653/DK/NIDDK NIH HHS/United States ; T32MH096678/U.S. Department of Health & Human Services ; NIH ; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/ ; R01 AI123394/AI/NIAID NIH HHS/United States ; R01 HD092414/HD/NICHD NIH HHS/United States ; T32 GM007067/GM/NIGMS NIH HHS/United States ; P30 DK052574/DK/NIDDK NIH HHS/United States ; 200-2016-91955/U.S. Department of Health & Human Services ; Centers for Disease Control and Prevention (CDC)/
• Volume:
  4
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f13a5024761165c8347382a3e61c73247c9c6461f8f53302079a8c25e1c601b5
• Download URL:
  https://stacks.cdc.gov/view/cdc/83426/cdc_83426_DS1.pdf
• File Type:
  [PDF - 2.34 MB ]