Indirect cohort analysis of 10-valent pneumococcal conjugate vaccine effectiveness against vaccine-type and vaccine-related invasive pneumococcal disease

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Verani, Jennifer R. ; Santos Domingues, Carla Magda A. ; de Moraes, José Cassio
• Corporate Authors:
  Brazilian Pneumococcal Conjugate Vaccine Effectiveness Study Group
• Description:
  We applied the indirect cohort method to estimate effectiveness of 10-valent pneumococcal conjugate vaccine (PCV10) among young children in Brazil. Cases of invasive pneumococcal disease (IPD), i.e., Streptococcus pneumoniae, detected in normally sterile fluid identified through laboratory-based surveillance and previously enrolled in a matched case-control effectiveness study are included. We estimated PCV10 effectiveness using multivariable logistic regression comparing PCV10 vaccination among children with vaccine-type or vaccine-related IPD vs. children with non-vaccine-type disease. The adjusted effectiveness of ≥ 1 doses against vaccine-type (72.8%, 95% confidence interval [CI] [44.1, 86.7]) and vaccine-related (61.3%, 95%CI [14.5, 82.5]) IPD were similar to the effectiveness observed in the original case-control study (which required enrollment >1200 controls). We also found significant protection of ≥ 1 dose against individual vaccine serotypes (14, 6B, 23F, 18C) and against vaccine-related serotype 19A. The indirect cohort methods leverages existing surveillance is a feasible approach for evaluating pneumococcal conjugate vaccines, particularly in resource-limited settings.
• Subjects:
  Article Bacteremia Brazil Case-control Studies Child, Preschool Cohort Studies Female Humans Infant Invasive Pneumococcal Disease Male Meningitis, Pneumococcal Pneumococcal Conjugate Vaccine Pneumococcal Vaccines Serogroup Streptococcus Pneumoniae Treatment Outcome Vaccine Effectiveness

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• Source:
  Vaccine. 33(46):6145-6148
• Pubmed ID:
  26469718
• Pubmed Central ID:
  PMC6859415
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  33
• Issue:
  46
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:803443bac825ad9b4b38349cf077aa1ae10ad9414e765d54c1088e688875db5c
• Download URL:
  https://stacks.cdc.gov/view/cdc/83100/cdc_83100_DS1.pdf
• File Type:
  [PDF - 209.94 KB ]