Sporotrichosis in the Highlands of Madagascar, 2013–20171

Rasamoelina, Tahinamandranto; Maubon, Danièle; Raharolahy, Onivola; Razanakoto, Harinjara; Rakotozandrindrainy, Njary; Rakotomalala, Fetra Angelot; Bailly, Sébastien; Sendrasoa, Fandresena; Ranaivo, Irina; Andrianarison, Malalaniaina; Rakotonirina, Benja; Andriantsimahavandy, Abel; Rabenja, Fahafahantsoa Rapelanoro; Andrianarivelo, Mala Rakoto; Ramarozatovo, Lala Soavina; Cornet, Muriel

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Sporotrichosis in the Highlands of Madagascar, 2013–20171

Supporting Files Public Domain

October 2019
By Rasamoelina, Tahinamandranto ; Maubon, Danièle ; Raharolahy, Onivola ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Rasamoelina, Tahinamandranto ; Maubon, Danièle ; Raharolahy, Onivola ; Razanakoto, Harinjara ; Rakotozandrindrainy, Njary ; Rakotomalala, Fetra Angelot ; Bailly, Sébastien ; Sendrasoa, Fandresena ; Ranaivo, Irina ; Andrianarison, Malalaniaina ; Rakotonirina, Benja ; Andriantsimahavandy, Abel ; Rabenja, Fahafahantsoa Rapelanoro ; Andrianarivelo, Mala Rakoto ; Ramarozatovo, Lala Soavina ; Cornet, Muriel
Description:

Sporotrichosis is a saprozoonotic fungal infection found mostly in tropical and subtropical areas. Few case reports in Madagascar have been published. To document sporotrichosis epidemiology in Madagascar, we conducted a cross-sectional study. During March 2013-June 2017, we recruited from select hospitals in Madagascar patients with chronic cutaneous lesions suggestive of dermatomycosis. Sporotrichosis was diagnosed for 63 (42.5%) of 148 patients. All but 1 patient came from the central highlands, where the prevalence was 0.21 cases/100,000 inhabitants. Frequency was high (64.7%) among patients <18 years of age. Sporotrichosis was diagnosed for 73.8% of patients with arm lesions, 32.3% with leg lesions, and 15.4% with lesions at other sites. Molecular identification identified 53 Sporothrix schenckii isolates. Among the 32 patients who were followed up, response to itraconazole was complete or major for 15 and minor for 17. Overall, endemicity of sporotrichosis in Madagascar was high, concentrated in the highlands.
Subjects:

Adolescent Adult Aged Aged, 80 And Over Age Factors Antifungal Agents Child Child, Preschool Cross-Sectional Studies Female Humans Itraconazole Male Middle Aged Polymerase Chain Reaction Prevalence Research Sporothrix Sporotrichosis Young Adult
Source:

Emerg Infect Dis. 25(10):1893-1902
Pubmed ID:

31538565
Pubmed Central ID:

PMC6759251
Document Type:

Journal Article
Place as Subject:

Madagascar
Location:

Africa
Volume:

25
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:fa7022016f385c6fdc09b52d183bfa18eb0bb8269a87e9f0749fa46ceae4a4df
Download URL:

https://stacks.cdc.gov/view/cdc/82968/cdc_82968_DS1.pdf
File Type:

[PDF - 1.81 MB ]

File Language:

English

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