Ethnicity and Cutaneous Melanoma in the City of Sao Paulo, Brazil: A Case-Control Study

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Luiz, Olinda C. ; Gianini, Reinaldo José ; Gonçalves, Fernanda T. ; Francisco, Guilherme ; Festa-Neto, Cyro ; Sanches, José Antonio ; Gattas, Gilka J. F. ; Chammas, Roger ; Eluf-Neto, José
• Description:
  Background
  
  Over the last century the incidence of cutaneous melanoma has increased worldwide, a trend that has also been observed in Brazil. The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. In addition, the incidence of melanoma might be influenced by ethnicity. Like many countries, Brazil has high immigration rates and consequently a heterogenous population. However, Brazil is unique among such countries in that the ethnic heterogeneity of its population is primarily attributable to admixture. This study aimed to evaluate the contribution of European ethnicity to the risk of cutaneous melanoma in Brazil.
  
  Methodology/Principal Findings
  
  We carried out a hospital-based case-control study in the metropolitan area of Sao Paulo, Brazil. We evaluated 424 hospitalized patients (202 melanoma patients and 222 control patients) regarding phenotypic features, sun exposure, and number of grandparents born in Europe. Through multivariate logistic regression analysis, we found the following variables to be independently associated with melanoma: grandparents born in Europe—Spain (OR = 3.01, 95% CI: 1.03–8.77), Italy (OR = 3.47, 95% CI: 1.41–8.57), a Germanic/Slavic country (OR = 3.06, 95% CI: 1.05–8.93), or ≥2 European countries (OR = 2.82, 95% CI: 1.06–7.47); eye color—light brown (OR = 1.99, 95% CI: 1.14–3.84) and green/blue (OR = 4.62; 95% CI 2.22–9.58); pigmented lesion removal (OR = 3.78; 95% CI: 2.21–6.49); no lifetime sunscreen use (OR = 3.08; 95% CI: 1.03–9.22); and lifetime severe sunburn (OR = 1.81; 95% CI: 1.03–3.19).
  
  Conclusions
  
  Our results indicate that European ancestry is a risk factor for cutaneous melanoma. Such risk appears to be related not only to skin type, eye color, and tanning capacity but also to others specific characteristics of European populations introduced in the New World by European immigrants.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Case-Control Studies Female Humans Logistic Models Male Melanoma Middle Aged Multivariate Analysis Risk Factors Skin Neoplasms Young Adult

  More +
• Source:
  PLoS One. 2012; 7(4).
• Document Type:
  Journal Article
• Place as Subject:
  Brazil
• Volume:
  7
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:566084a6e8faa14f1858054c9bce9d542187e46f0d2313ac84a9d59ee4d57b8f
• Download URL:
  https://stacks.cdc.gov/view/cdc/8187/cdc_8187_DS1.pdf
• File Type:
  [PDF - 94.09 KB ]