Trends in apolipoprotein B, non-high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol for adults aged 20 and over, 2005–2016

Details

• Corporate Authors:
  National Center for Health Statistics (U.S.)
• Description:
  Objectives—Guidelines for lowering cholesterol have focused on total and low- density lipoprotein cholesterol (LDL–C). Although the emphasis remains on LDL–C, more attention is now being given to apolipoprotein B (apo B) and non-high-density lipoprotein cholesterol (non-HDL–C). This report presents trends in mean apo B, non-HDL–C, and LDL–C in adults aged 20 and over from 2005–2006 through 2015–2016. ; Methods—Data from the 2005–2016 National Health and Nutrition Examination Surveys were used to conduct trend analyses. Means and standard errors of the mean for apo B (n = 13,802), non-HDL–C (n = 30,921), and LDL–C (n = 13,559) are presented overall and by sex, stratified by age, race and Hispanic origin, and body mass index (BMI) category for each 2-year survey cycle. Trends over time were tested using orthogonal contrast matrices and piecewise and multiple linear regression. ; Results—In men, apo B declined from 98 mg/dL in 2005–2006 to 93 mg/dL in 2011–2012, but did not change after 2011–2012. Declining trends were also seen ; for men in non-HDL–C (147 to 141 mg/dL) and LDL–C (116 to 114 mg/dL) from 2005–2006 to 2015–2016. For women, age-adjusted mean apo B declined from ; 94 mg/dL in 2005–2006 to 91 mg/dL in 2015–2016. Non-HDL–C and LDL–C in women did not change significantly from 2005–2006 to 2011–2012, but non-HDL–C declined from 141 mg/dL in 2011–2012 to 133 mg/dL in 2015–2016, and LDL–C declined from 117 mg/dL in 2011–2012 to 111 mg/dL in 2015–2016. With the exception of LDL–C in men, these trends persisted after controlling for age, race and Hispanic origin, BMI, and lipid-lowering medication use. ; Conclusions—From 2005–2006 to 2015–2016, significant but different declining trends in apo B, non-HDL–C, and LDL–C were seen in men and women. In general, differences in age, race and Hispanic origin, BMI category, and lipid-lowering medication use did not explain the trends. ; Suggested citation: Carroll MD, Kruszon-Moran D, Tolliver E. Trends in apolipoprotein B, non-high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol for adults aged 20 and over, 2005–2016. National Health Statistics Reports; no 127. Hyattsville, MD: National Center for Health Statistics. 2019. ; CS309775 ; nhsr127-508.pdf
• Content Notes:
  National health statistics reports ; no. 127 ; DHHS publication ; no. 2019-1250
• Subjects:
  • Adult
  • Apolipoproteins B
  • Cholesterol/blood
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Prevalence
• Series:
  National Health Statistics Reports
• Document Type:
  Text
• Genre:
  Report ; Statistics
• Place as Subject:
  United States
• CIO:
  National Center for Health Statistics
• Topic:
  Health Statistics
• Volume:
  127
• Download URL:
  https://stacks.cdc.gov/view/cdc/81727/cdc_81727_DS1.pdf
• File Type:
  [PDF - 524.94 KB]
• Collection(s):
  National Center for Health Statistics
• Main Document Checksum:
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