Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV Infection

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Ananworanich, Jintanat ; Schuetz, Alexandra ; Vandergeeten, Claire ; Sereti, Irini ; de Souza, Mark ; Rerknimitr, Rungsun ; Dewar, Robin ; Marovich, Mary ; van Griensven, Frits ; Sekaly, Rafick ; Pinyakorn, Suteeraporn ; Phanuphak, Nittaya ; Trichavaroj, Rapee ; Rutvisuttinunt, Wiriya ; Chomchey, Nitiya ; Paris, Robert ; Peel, Sheila ; Valcour, Victor ; Maldarelli, Frank ; Chomont, Nicolas ; Michael, Nelson ; Phanuphak, Praphan ; Kim, Jerome H.
• Corporate Authors:
  on behalf of the RV254/SEARCH 010 Study Group
• Description:
  Background
  
  Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy.
  
  Methods and Findings
  
  We prospectively screened 24,430 subjects in Bangkok and identified 40 AHI individuals. Thirty Thais were enrolled (8 Fiebig I, 5 Fiebig II, 15 Fiebig III, 2 Fiebig IV) of whom 15 completed 24 weeks of megaHAART (tenofovir/emtricitabine/efavirenz/raltegravir/maraviroc). Sigmoid biopsies were completed in 24/30 at baseline and 13/15 at week 24.
  
  Conclusions
  
  Gut T cell depletion and HIV reservoir seeding increases with progression of AHI. MegaHAART was associated with immune restoration and reduced reservoir size. Our findings could inform research on strategies to achieve HIV drug-free remission.
  
  
• Subjects:
  Adult Antiretroviral Therapy, Highly Active CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Cytokines Female HIV-1 HIV Infections Humans Intestines Leukocytes, Mononuclear Male Receptors, CCR5 T-Lymphocytes Treatment Outcome Viral Load Virus Latency

  More +
• Source:
  PLoS One. 2012; 7(3).
• Document Type:
  Journal Article
• Volume:
  7
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1243e622a32654eb1ab533d9171a1c4e1a280dd833a6e6643591bf4d039b728d
• Download URL:
  https://stacks.cdc.gov/view/cdc/8171/cdc_8171_DS1.pdf
• File Type:
  [PDF - 655.47 KB ]