Details:

Alternative Title:
Pediatrics
Personal Author:
Weber, David R. ; Hadjiyannakis, Stasia ; McMillan, Hugh J. ; Noritz, Garey ; Ward, Leanne M.
Weber, David R. ; Hadjiyannakis, Stasia ; McMillan, Hugh J. ; Noritz, Garey ; Ward, Leanne M. Less -
Description:
Duchenne muscular dystrophy (DMD) is associated with an increased risk of endocrine complications due to the effects of prolonged glucocorticoid therapy as well as progressive muscle weakness. Categories of complications include obesity and its comorbidities, short stature, pubertal delay, and adrenal insufficiency. Obesity prevention is important for long-term management of patients with DMD. Preventing glucocorticoid-induced weight gain fosters patient mobility, ease of transfer, and reduces sleep-disordered breathing. Metabolic complications from obesity (glucose intolerance, dyslipidemia) also can be avoided. Short stature and pubertal delay may negatively affect self-esteem and peer relationships, and careful monitoring of growth and pubertal development can allow anticipatory counseling. Adrenal insufficiency, a potentially life-threatening complication associated with prolonged glucocorticoid use, must be recognized so as to allow prompt treatment. In this article, we provide a summary of current guidance to ensure comprehensive endocrine management is followed in patients with DMD.
Subject:
[+]
Article Endocrine System Diseases Glucocorticoids Humans Muscular Dystrophy, Duchenne Obesity Practice Guidelines As Topic
Source:
Pediatrics. 142(Suppl 2):S43-S52
Pubmed ID:
30275248
Pubmed Central ID:
PMC6460463
Document Type:
Journal Article
Funding:
CIHR/Canada ; K12 HD068373/HD/NICHD NIH HHS/United States ; K23 DK114477/DK/NIDDK NIH HHS/United States ; U38 OT000167/OT/OSTLTS CDC HHS/United States
CIHR/Canada ; K12 HD068373/HD/NICHD NIH HHS/United States ; K23 DK114477/DK/NIDDK NIH HHS/United States ; U38 OT000167/OT/OSTLTS CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:cfa604ec463654f93226eca1efd3b538d6cd11c4d90e74d175942be0ea455b89
Download URL:
https://stacks.cdc.gov/view/cdc/81694/cdc_81694_DS1.pdf
File Type:

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