Details:

Alternative Title:
Nat Commun
Personal Author:
Pinsent, Amy ; Solomon, Anthony W. ; Bailey, Robin L. ; Bid, Rhiannon ; Cama, Anaseini ; ... More +
Pinsent, Amy ; Solomon, Anthony W. ; Bailey, Robin L. ; Bid, Rhiannon ; Cama, Anaseini ; Dean, Deborah ; Goodhew, Brook ; Gwyn, Sarah E. ; Jack, Kelvin R. ; Kandel, Ram Prasad ; Kama, Mike ; Massae, Patrick ; Macleod, Colin ; Mabey, David C. W. ; Migchelsen, Stephanie ; Müller, Andreas ; Sandi, Frank ; Sokana, Oliver ; Taoaba, Raebwebwe ; Tekeraoi, Rabebe ; Martin, Diana L. ; White, Michael. T. Less -
Description:
Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, we analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low-transmission and post-elimination settings. Analyses with sero-catalytic and antibody acquisition models provide insights into transmission history within each population. To accurately estimate sero-conversion rates (SCR) for trachoma in populations with high-seroprevalence in adults, the model accounts for secondary exposure to Chlamydia trachomatis due to urogenital infection. We estimate the population half-life of sero-reversion for anti-Pgp3 antibodies to be 26 (95% credible interval (CrI): 21-34) years. We show SCRs below 0.015 (95% confidence interval (CI): 0.0-0.049) per year correspond to a prevalence of trachomatous inflammation-follicular below 5%, the current threshold for elimination of active trachoma as a public health problem. As global trachoma prevalence declines, we may need cross-sectional serological survey data to inform programmatic decisions.
Subjects:
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Adolescent Adult Age Factors Article Child Child, Preschool Chlamydia Trachomatis Female Humans Infant Models, Statistical Public Health Surveillance Seroepidemiologic Studies Trachoma Young Adult
Source:
Nat Commun. 9
Pubmed ID:
30575720
Pubmed Central ID:
PMC6303365
Document Type:
Journal Article
Funding:
001/World Health Organization/International
Place as Subject:
Africa South of the Sahara ; Nepal ; Pacific Islands
Africa South of the Sahara ; Nepal ; Pacific Islands Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:84e5ffc6315cd4dec526e2a306e7faee2574429f2abbe87dd7256b8994b36dc0
Download URL:
https://stacks.cdc.gov/view/cdc/81496/cdc_81496_DS1.pdf
File Type:

Supporting Files

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