i
Impaired Clearance and Enhanced Pulmonary Inflammatory/Fibrotic Response to Carbon Nanotubes in Myeloperoxidase-Deficient Mice
-
Mar 30 2012
Source: PLoS One. 2012; 7(3). -
Alternative Title:PLoS One
-
Publisher's site:
-
Personal Author:
-
Description:Advancement of biomedical applications of carbonaceous nanomaterials is hampered by their biopersistence and pro-inflammatory action in vivo. Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the lungs of these animals after pharyngeal aspiration was markedly less effective whereas the inflammatory response was more robust than in wild-type C57Bl/6 mice. Our results provide direct evidence for the participation of MPO - one of the key-orchestrators of inflammatory response - in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of nanomaterials through genetic or pharmacological manipulations.
-
Subject:
-
Source:
-
Pubmed ID:22479306
-
Pubmed Central ID:PMC3316527
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
-
jpeg gif jpeg txt tiff doc txt gif jpeg gif jpeg gif jpeg gif
Details:
Supporting Files
More +