Total, free, and percent free prostate-specific antigen levels among U.S. men, 2001-04

Lacher, David A.; Thompson, Trevor D.; Jeffery P. Hughes,; Saraiya, Mona

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Total, free, and percent free prostate-specific antigen levels among U.S. men, 2001-04

June 29, 2007
By Lacher, David A. ; Thompson, Trevor D. ; Jeffery P. Hughes, ; ...
Series: Advance data from vital and health statistics of the National Center for Health Statistics ; no. 379

[PDF-314.69 KB]

English

Details You May Also Like

Details:

Personal Author:

Lacher, David A. ; Thompson, Trevor D. ; Jeffery P. Hughes, ; Saraiya, Mona

Lacher, David A. ; Thompson, Trevor D. ; Jeffery P. Hughes, ; Saraiya, Mona Less -
Corporate Authors:

National Center for Health Statistics (U.S.) ; National Center for Chronic Disease Prevention and Health Promotion (U.S.)

National Center for Health Statistics (U.S.) ; National Center for Chronic Disease Prevention and Health Promotion (U.S.) Less -
Description:

OBJECTIVE: Screening for prostate cancer using prostate-specific antigen (PSA) tests is common but remains controversial. Total PSA using thresholds of 4.0 and 2.5 ng/mL has been used for screening men. In addition, the percent free PSA (free PSA/total PSA x 100%) using thresholds of less than 25% and 15% have been proposed for use in screening for prostate cancer in conjunction with the total PSA. The distributions of total PSA, free PSA, and percent free PSA, which vary with age and race-ethnicity among American men, would help determine the burden of screening using different thresholds of PSA tests.

METHODS: PSA tests were performed on serum samples from men age 40 years and older (n = 2,546) who participated in the 2001-04 National Health and Nutrition Examination Survey (NHANES). Total, free and percent free PSA were estimated for Mexican American, non-Hispanic white, and non-Hispanic black men.

RESULTS: About 6.2%, (95% confidence interval, 95% CI: 5.2-7.2%), corresponding to an estimated 3.6 million (95% CI: 3.0-4.2 million) men 40 years of age and older, had a total PSA of greater than or equal to 4.0 ng/mL. Approximately 3.6% (95% CI: 1.8-6.2%) of Mexican American men, 6.2% (95% CI: 5.1-7.6%) of non-Hispanic white men, and 7.8% (95% CI: 5.2-11.1 ) of non-Hispanic black men had total PSA of 4.0 ng/mL or more. Approximately 13.1 (95% CI: 11.7-14.5%) of men 40 years of age and older had total PSA greater than or equal to 2.5 ng/mL. For men with total PSA less than 2.5 ng/mL, 23.1% (95% CI: 21.0-25.3%) had a percent free PSA between 15% and 25%, and 5.0% had free PSA (95% CI: 3.9-6.4%) less than or equal to 15%.

CONCLUSIONS: The effect of lowering the total PSA thresholds increases the number of U.S. men who would be referred for screening for prostate cancer. Total and free PSA increased with age in Mexican American, non-Hispanic white, and non-Hispanic black men. Information about the distribution of total, free, and percent free PSA will help guide public health policy in screening for prostate cancer.

Suggested citation: Lacher DA, Thompson TD, Hughes JP, Saraiya M. Total, free, and percent free prostate-specific antigen levels among U.S. men, 2001–04. Advance data from vital and health statistics; no 379. Hyattsville, MD: National Center for Health Statistics. 2006.

06-0151 (12/06)

CS107046

T26957

PMID: 17348177

ad379.pdf
Subjects:

[+]

Adult Aged Aged, 80 And Over Black Or African American Hispanic Or Latino Humans Male Mass Screening Middle Aged Nutrition Surveys Prostate-Specific Antigen/analysis Prostate-Specific Antigen/blood Prostatic Neoplasms/diagnosis White
Series:

Advance data from vital and health statistics of the National Center for Health Statistics ; no. 379 ; DHEW publication ; no. (OHS) 2007-1250.

Advance data from vital and health statistics of the National Center for Health Statistics ; no. 379 ; DHEW publication ; no. (OHS) 2007-1250. Less -
Document Type:

Journal Issue
Name as Subject:

National Hospital Ambulatory Medical Care Survey (U.S.) ; National Hospital Ambulatory Medical Care Survey (U.S.)

National Hospital Ambulatory Medical Care Survey (U.S.) ; National Hospital Ambulatory Medical Care Survey (U.S.) Less -
Genre:

Statistics
Place as Subject:

United States
Collection(s):

Stephen B. Thacker CDC Library collection
Main Document Checksum:

[+]

urn:sha256:85b83f091ea63fdaeaa27f84169f0ab94dde236791a9b304cb845846b3dcf3b2
Download URL:

https://stacks.cdc.gov/view/cdc/81334/cdc_81334_DS1.pdf
File Type:

No Additional Files

More +

Total, free, and percent free prostate-specific antigen levels among U.S. men, 2001-04

Details:

Supporting Files

You May Also Like