Estimates of the timing of reductions in genital warts and high grade cervical intraepithelial neoplasia after onset of human papillomavirus (HPV) vaccination in the United States

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Chesson, Harrell W. ; Ekwueme, Donatus U. ; Saraiya, Mona ; Dunne, Eileen F. ; Markowitz, Lauri E.
• Description:
  Background:
  
  The objective of this study was to estimate the number of years after onset of a quadrivalent HPV vaccination program before notable reductions in genital warts and cervical intraepithelial neoplasia (CIN) will occur in teenagers and young adults in the United States.
  
  Methods:
  
  We applied a previously published model of HPV vaccination in the United States and focused on the timing of reductions in genital warts among both sexes and reductions in CIN 2/3 among females. Using different coverage scenarios, the lowest being consistent with current 3-dose coverage in the United States, we estimated the number of years before reductions of 10%, 25%, and 50% would be observed after onset of an HPV vaccination program for ages 12–26 years.
  
  Results:
  
  The model suggested female-only HPV vaccination in the intermediate coverage scenario will result in a 10% reduction in genital warts within 2–4 years for females aged 15–19 years and a 10% reduction in CIN 2/3 among females aged 20–29 years within 7–11 years. Coverage had a major impact on when reductions would be observed. For example, in the higher coverage scenario a 25% reduction in CIN2/3 would be observed with 8 years compared with 15 years in the lower coverage scenario.
  
  Conclusions:
  
  Our model provides estimates of the potential timing and magnitude of the impact of HPV vaccination on genital warts and CIN 2/3 at the population level in the United States. Notable, population-level impacts of HPV vaccination on genital warts and CIN 2/3 can occur within a few years after onset of vaccination, particularly among younger age groups. Our results are generally consistent with early reports of declines in genital warts among youth.
  
  
• Subjects:
  Adolescent Adult Cervical Intraepithelial Neoplasia Child Condylomata Acuminata Female Genital Diseases, Female Genital Diseases, Male Humans Immunization Programs Male Models, Theoretical Papillomavirus Vaccines Uterine Cervical Neoplasms Young Adult

  More +
• Source:
  Vaccine. 31(37):3899-3905
• Pubmed ID:
  23820080
• Pubmed Central ID:
  PMC6727206
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  31
• Issue:
  37
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6b5e5bfecc5a96915c8e1da65dd019943a7525b63bf965e56eb988196588e0e3
• Download URL:
  https://stacks.cdc.gov/view/cdc/81248/cdc_81248_DS1.pdf
• File Type:
  [PDF - 358.97 KB ]