Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients

Bellanger, Anne-Pauline; Berceanu, Ana; Scherer, Emeline; Desbrosses, Yohan; Daguindau, Etienne; Rocchi, Steffi; Millon, Laurence

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Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients

Supporting Files Public Domain

Sep 2019
By Bellanger, Anne-Pauline ; Berceanu, Ana ; Scherer, Emeline ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Bellanger, Anne-Pauline ; Berceanu, Ana ; Scherer, Emeline ; Desbrosses, Yohan ; Daguindau, Etienne ; Rocchi, Steffi ; Millon, Laurence
Description:

We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.
Subjects:

Antifungal Agents Aspergillus Fumigatus Diagnosis, Differential Fatal Outcome Humans Immunocompromised Host Leukemia, Myeloid, Acute Male Middle Aged Nitriles Pulmonary Aspergillosis Pyridines Treatment Failure Triazoles
Source:

Emerg Infect Dis. 25(9):1778-1779
Pubmed ID:

31441760
Pubmed Central ID:

PMC6711214
Document Type:

Journal Article
Genre:

Letter
Place as Subject:

France
Volume:

25
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:099a3aaad2fc4988ba9216805e564b2f89eb1742a4dfcb54a72cb77d1886a318
Download URL:

https://stacks.cdc.gov/view/cdc/81178/cdc_81178_DS1.pdf
File Type:

[PDF - 431.53 KB ]

File Language:

English

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