Clinical Characteristics and Treatment Outcomes for Patients Infected with Mycobacterium haemophilum

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nookeu, Pornboonya ; Angkasekwinai, Nasikarn ; Foongladda, Suporn ; Phoompoung, Pakpoom
• Description:
  Mycobacterium haemophilum is a nontuberculous mycobacterium that can infect immunocompromised patients. Because of special conditions required for its culture, this bacterium is rarely reported and there are scarce data for long-term outcomes. We conducted a retrospective study at Siriraj Hospital, Bangkok, Thailand, during January 2012-September 2017. We studied 21 patients for which HIV infection was the most common concurrent condition. The most common organ involvement was skin and soft tissue (60%). Combination therapy with macrolides and fluoroquinolones resulted in a 60% cure rate for cutaneous infection; adding rifampin as a third drug for more severe cases resulted in modest (66%) cure rate. Efficacy of medical therapy in cutaneous, musculoskeletal, and ocular diseases was 80%, 50%, and 50%, respectively. All patients with central nervous system involvement showed treatment failures. Infections with M. haemophilum in HIV-infected patients were more likely to have central nervous system involvement and tended to have disseminated infections and less favorable outcomes.
• Subjects:
  Bacteria Clinical Characteristics Infection Mycobacterium Haemophilum Nontuberculous Mycobacteria Synopsis Treatment Outcomes Tuberculosis And Other Mycobacteria
• Source:
  Emerg Infect Dis. 25(9):1648-1652
• Pubmed ID:
  31441427
• Pubmed Central ID:
  PMC6711220
• Document Type:
  Journal Article
• Place as Subject:
  Bangkok, Thailand
• Location:
  Asia
• Volume:
  25
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1353807520d7a03fe02e6b2a16fa8f6ad4c9c6e8be2fc6048af5bdbd2cc1212b
• Download URL:
  https://stacks.cdc.gov/view/cdc/81172/cdc_81172_DS1.pdf
• File Type:
  [PDF - 1.13 MB ]