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Defying birth defects through diet?
  • Published Date:
    Feb 09 2011
  • Source:
    Genome Med. 2011; 3(2):9.
Filetype[PDF-235.42 KB]


Details:
  • Description:
    The risk of certain birth defects can be modified by maternal diet. A high-fat maternal mouse diet has recently been reported to substantially increase the penetrance of birth defects known to be associated with a deficiency of transcription factor Cited2 as well as induce cleft palate. These effects were associated with a more than twofold reduction in embryonic expression of Pitx2c. This investigation suggests the need to further explore this provocative gene-diet interaction in human studies.

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