Details:

Alternative Title:
Environ Health Perspect
Personal Author:
Schecter, Arnold ; Malik-Bass, Noor ; Calafat, Antonia M. ; Kato, Kayoko ; Colacino, Justin A. ; ... More +
Schecter, Arnold ; Malik-Bass, Noor ; Calafat, Antonia M. ; Kato, Kayoko ; Colacino, Justin A. ; Gent, Tyra L. ; Hynan, Linda S. ; Harris, T. Robert ; Malla, Sunitha ; Birnbaum, Linda ; Less -
Description:
For > 50 years, polyfluoroalkyl compounds (PFCs) have been used worldwide, mainly as surfactants and emulsifiers, and human exposure to some PFCs is widespread.|Our goal was to report PFC serum concentrations from a convenience sample of Dallas, Texas, children from birth to < 13 years of age, and to examine age and sex differences in PFC concentrations.|We analyzed 300 serum samples collected in 2009 for eight PFCs by online solid phase extraction-high performance liquid chromatography-isotope dilution-tandem mass spectrometry.|Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were detected in > 92% of participants; the other PFCs measured were detected less frequently. Overall median concentrations of PFOS (4.1 ng/mL) were higher than those for PFOA (2.85 ng/mL), PFNA (1.2 ng/mL), and PFHxS (1.2 ng/mL). For PFOS, PFOA, PFNA, and PFHxS, we found no significant differences (p < 0.05) by sex, significantly increasing concentrations for all four chemicals by age, and significantly positive correlations between all four compounds.|We found no significant differences in the serum concentrations of PFOS, PFOA, PFNA, and PFHxS by sex, but increasing concentrations with age. Our results suggest that these 300 Texas children from birth through 12 years of age continued to be exposed to several PFCs in late 2009, years after changes in production of some PFCs in the United States.
Subject:
[+]
Age Factors
Child
Child, Preschool
Chromatography, High Pressure Liquid
Environmental Exposure
Environmental Pollutants
Female
Fluorocarbons
Humans
Indicator Dilution Techniques
Infant
Infant, Newborn
Male
Research
Sex Factors
Solid Phase Extraction
Statistics, Nonparametric
Tandem Mass Spectrometry

Source:
Environ Health Perspect. 2011; 120(4):590-594.
Document Type:
Journal Article ;
Place as Subject:
Texas ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:53525268c4a863e731187602a6456ee364de181235f1eb3fad51a9479836df40
File Type:

Supporting Files

• 	ehp.1104325.nxml	txt
  	license.txt	txt

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