Details:

Alternative Title:
Cerebellum
Personal Author:
Shakkottai, Vikram G. ; Batla, Amit ; Bhatia, Kailash ; Dauer, William T ; Dresel, Christian ; ... More +
Shakkottai, Vikram G. ; Batla, Amit ; Bhatia, Kailash ; Dauer, William T ; Dresel, Christian ; Niethammer, Martin ; Eidelberg, David ; Raike, Robert S. ; Smith, Yoland ; Jinnah, H. A. ; Hess, Ellen J. ; Meunier, Sabine ; Hallett, Mark ; Fremont, Rachel ; Khodakhah, Kamran ; LeDoux, Mark S. ; Popa, Traian ; Gallea, Cécile ; Lehericy, Stéphane ; Bostan, Andreea C. ; Strick, Peter L. Less -
Description:
A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated movement, is widely accepted. Recent work has suggested that alterations in activity, connectivity, and structure of the cerebellum are also associated with dystonia, a neurological disorder characterized by abnormal and sustained muscle contractions often leading to abnormal maintained postures. In this manuscript, the authors discuss their views on how the cerebellum may play a role in dystonia. The following topics are discussed: The relationships between neuronal/network dysfunctions and motor abnormalities in rodent models of dystonia. Data about brain structure, cerebellar metabolism, cerebellar connections, and noninvasive cerebellar stimulation that support (or not) a role for the cerebellum in human dystonia. Connections between the cerebellum and motor cortical and sub-cortical structures that could support a role for the cerebellum in dystonia. Overall points of consensus include: Neuronal dysfunction originating in the cerebellum can drive dystonic movements in rodent model systems. Imaging and neurophysiological studies in humans suggest that the cerebellum plays a role in the pathophysiology of dystonia, but do not provide conclusive evidence that the cerebellum is the primary or sole neuroanatomical site of origin.
Subject:
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Animals
Article
Ataxia
Cerebellum
Circuits
Dystonia
DYT1
Humans
Networks
Neural Pathways

Source:
Cerebellum. 16(2):577-594
Pubmed ID:
27734238
Pubmed Central ID:
PMC5336511
Document Type:
Journal Article
Funding:
P40 OD010996/ODCDC CDC HHS/Office of the Director/United States ; R01 NS079750/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; P51 OD011132/ODCDC CDC HHS/Office of the Director/United States ; R25 MH086466/NIMH NIH HHS/National Institute of Mental Health/United States ; R01 NS024328/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; ... More +
P40 OD010996/ODCDC CDC HHS/Office of the Director/United States ; R01 NS079750/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; P51 OD011132/ODCDC CDC HHS/Office of the Director/United States ; R25 MH086466/NIMH NIH HHS/National Institute of Mental Health/United States ; R01 NS024328/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; R01 NS082296/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; P30 NS076405/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; R01 NS085054/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; R01 NS050808/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; U54 TR001456/NCATS NIH HHS/National Center for Advancing Translational Sciences/United States ; R01 NS069936/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; U54 NS065701/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; R01 NS088528/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; K08 NS072158/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:cd2e3ca438db62110ad2fca8d1ecb9f93a00de19085132220561f9369d6c04f3
File Type:

Supporting Files

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