Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia

Details

• Alternative Title:
  Cerebellum
• Personal Author:
  Shakkottai, Vikram G. ; Batla, Amit ; Bhatia, Kailash ; Dauer, William T ; Dresel, Christian ; Niethammer, Martin ; Eidelberg, David ; Raike, Robert S. ; Smith, Yoland ; Jinnah, H. A. ; Hess, Ellen J. ; Meunier, Sabine ; Hallett, Mark ; Fremont, Rachel ; Khodakhah, Kamran ; LeDoux, Mark S. ; Popa, Traian ; Gallea, Cécile ; Lehericy, Stéphane ; Bostan, Andreea C. ; Strick, Peter L.
• Description:
  A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated movement, is widely accepted. Recent work has suggested that alterations in activity, connectivity, and structure of the cerebellum are also associated with dystonia, a neurological disorder characterized by abnormal and sustained muscle contractions often leading to abnormal maintained postures. In this manuscript, the authors discuss their views on how the cerebellum may play a role in dystonia. The following topics are discussed: The relationships between neuronal/network dysfunctions and motor abnormalities in rodent models of dystonia. Data about brain structure, cerebellar metabolism, cerebellar connections, and noninvasive cerebellar stimulation that support (or not) a role for the cerebellum in human dystonia. Connections between the cerebellum and motor cortical and sub-cortical structures that could support a role for the cerebellum in dystonia. Overall points of consensus include: Neuronal dysfunction originating in the cerebellum can drive dystonic movements in rodent model systems. Imaging and neurophysiological studies in humans suggest that the cerebellum plays a role in the pathophysiology of dystonia, but do not provide conclusive evidence that the cerebellum is the primary or sole neuroanatomical site of origin.
• Subjects:
  Animals Article Ataxia Cerebellum Circuits Dystonia DYT1 Humans Networks Neural Pathways
• Source:
  Cerebellum. 16(2):577-594
• Pubmed ID:
  27734238
• Pubmed Central ID:
  PMC5336511
• Document Type:
  Journal Article
• Funding:
  P40 OD010996/ODCDC CDC HHS/Office of the Director/United States ; R01 NS079750/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; P51 OD011132/ODCDC CDC HHS/Office of the Director/United States ; R25 MH086466/NIMH NIH HHS/National Institute of Mental Health/United States ; R01 NS024328/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; R01 NS082296/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; P30 NS076405/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; R01 NS085054/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; R01 NS050808/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; U54 TR001456/NCATS NIH HHS/National Center for Advancing Translational Sciences/United States ; R01 NS069936/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; U54 NS065701/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; R01 NS088528/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; K08 NS072158/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States
• Volume:
  16
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cd2e3ca438db62110ad2fca8d1ecb9f93a00de19085132220561f9369d6c04f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/80483/cdc_80483_DS1.pdf
• File Type:
  [PDF - 1.23 MB ]