Sequential infection with common pathogens promotes human-like immune gene expression and altered vaccine response

Details

• Alternative Title:
  Cell Host Microbe
• Personal Author:
  Reese, Tiffany A. ; Bi, Kevin ; Kambal, Amal ; Filali-Mouhim, Ali ; Beura, Lalit K. ; Bürger, Matheus C. ; Pulendran, Bali ; Sekaly, Rafick ; Jameson, Stephen C. ; Masopust, David ; Haining, W. Nicholas ; Virgin, Herbert W.
• Description:
  Immune responses differ between laboratory mice and humans. Chronic infection with viruses and parasites are common in humans, but are absent in laboratory mice, and thus represent potential contributors to inter-species differences in immunity. To test this, we sequentially infected laboratory mice with herpesviruses, influenza, and an intestinal helminth and compared their blood immune signatures to mock-infected mice before and after vaccination against yellow fever virus (YFV-17D). Sequential infection altered pre- and post-vaccination gene expression, cytokines, and antibodies in blood. Sequential pathogen exposure induced gene signatures that recapitulated those seen in blood from pet store-raised versus laboratory mice, and adult versus cord blood in humans. Therefore, basal and vaccine-induced murine immune responses are altered by infection with agents common outside of barrier facilities. This raises the possibility that we can improve mouse models of vaccination and immunity by selective microbial exposure of laboratory animals to mimic that of humans.
• Subjects:
  Animals Antibodies Antibodies, Viral Article Coinfection Cytokines Disease Models, Animal Fetal Blood Gene Expression Helminthiasis Herpesviridae Herpesviridae Infections Humans Immunity, Innate Immunoglobulin G Influenza, Human Intestinal Diseases, Parasitic Mice Mice, Inbred C57BL Orthomyxoviridae Infections Yellow Fever Yellow Fever Vaccine Yellow Fever Virus

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• Source:
  Cell Host Microbe. 19(5):713-719
• Pubmed ID:
  27107939
• Pubmed Central ID:
  PMC4896745
• Document Type:
  Journal Article
• Funding:
  R37 AI048638/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; R01 DK101354/NIDDK NIH HHS/National Institute of Diabetes and Digestive and Kidney Diseases/United States ; P30 CA077598/NCI NIH HHS/National Cancer Institute/United States ; P51 OD011132/ODCDC CDC HHS/Office of the Director/United States ; U19 AI057266/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; R56 AI048638/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; R37 DK057665/NIDDK NIH HHS/National Institute of Diabetes and Digestive and Kidney Diseases/United States ; P30 AR048335/NIAMS NIH HHS/National Institute of Arthritis and Musculoskeletal and Skin Diseases/United States ; R01 AI111918/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; R01 AI048638/NIAID NIH HHS/National Institute of Allergy and Infectious Diseases Extramural Activities/United States ; R01 OD011170/ODCDC CDC HHS/Office of the Director/United States ; R24 OD019793/ODCDC CDC HHS/Office of the Director/United States
• Volume:
  19
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:22115d7d427f4f03b3b258f7105fbc890d974c0e5b49f263a08735219ee46127
• Download URL:
  https://stacks.cdc.gov/view/cdc/80475/cdc_80475_DS1.pdf
• File Type:
  [PDF - 1.43 MB ]